Manfred Zimmermann

TL;DR: The Committee for Research and Ethical Issues of the International Association for the Study of Pain (IASP®) is concerned with the ethical aspects of studies producing experimental pain and any suffering it may cause in animals.

TL;DR: Findings suggest that a shift in the ratio of cell death repressor Bcl-2 to cell death effector Bax and a concomitant activation of c-Fos may contribute to neuronal apoptosis in the infarcted thalamus and cortex.

TL;DR: In adult rats, expression of c-JUN, Jun B, JUN D, c-FOS, FOS B, KROX-24 and CREB proteins was investigated by immunocytochemistry in L4 and L5 dorsal root ganglia and lumbar spinal cord for up to 300 days following transection of the left sciatic nerve.

TL;DR: It is demonstrated for the first time that inducible transcription factors such as c‐Fos and JunB are an essential part of fundamental biological processes in the adult mammalian nervous system, e.g. of light‐induced phase shifts of the circadian pacemaker.

TL;DR: Investigation of the expression of c‐Jun, JunB, JunD, c‐Fos, FosB, and Krox proteins in the brain of untreated male Sprague‐Dawley and female BDIX rats by immunocytochemistry using specific antibodies provides new insights into the ability of neurons to react with changes of gene expression to external stimulation under physiological or pathological conditions.