M
Manish Pathak
Researcher at Emory University
Publications - 19
Citations - 641
Manish Pathak is an academic researcher from Emory University. The author has contributed to research in topics: Silver nanoparticle & Liver receptor homolog-1. The author has an hindex of 9, co-authored 18 publications receiving 552 citations. Previous affiliations of Manish Pathak include University of Maryland, College Park & Sam Higginbottom Institute of Agriculture, Technology and Sciences.
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Journal ArticleDOI
A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects
Jae Man Lee,Yoon Kwang Lee,Yoon Kwang Lee,Jennifer L. Mamrosh,Scott A. Busby,Patrick R. Griffin,Manish Pathak,Eric A. Ortlund,David D. Moore +8 more
TL;DR: Findings identify an LRH-1 dependent phosphatidylcholine signalling pathway that regulates bile acid metabolism and glucose homeostasis and both the antidiabetic and lipotropic effects are lost in liver-specific Lrh-1 knockouts.
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Hydrophobic environment is a key factor for the stability of thermophilic proteins.
TL;DR: The notion of surrounding hydrophobicity, which characterizes the hydrophobic behavior of residues in a protein environment, has been applied to the three‐dimensional structures of elongation factor‐Tu proteins and it is found that the thermophilic proteins are enriched with a hydrophilic environment.
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Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation
Paul M. Musille,Manish Pathak,Janelle L. Lauer,William H. Hudson,Patrick R. Griffin,Eric A. Ortlund +5 more
TL;DR: It is shown that the lipid-free receptor undergoes previously unrecognized structural fluctuations, allowing it to interact with widely expressed co-repressors, enhancing the understanding of LRH-1 regulation and highlighting its importance as a new therapeutic target for controlling diabetes.
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A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress–induced membrane biogenesis
Jihui Ren,Jihui Ren,Coney Pei-Chen Lin,Manish Pathak,Brenda Temple,Aaron H. Nile,Carl J. Mousley,Mara C. Duncan,Debra M. Eckert,Thomas J. Leiker,Pavlina T. Ivanova,David S. Myers,Robert C. Murphy,H. Alex Brown,Jolien S. Verdaasdonk,Kerry Bloom,Eric A. Ortlund,Aaron M. Neiman,Vytas A. Bankaitis +18 more
TL;DR: The Sec14-like phosphatidylinositol transfer protein Sfh3 associates with bulk LDs in vegetative cells but targets to a neutral lipid hydrolase-rich LD pool during sporulation, and this inhibition prevents prospore membrane biogenesis in sporulating cells.
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Design, Facile Synthesis, and Antibacterial Activity of Hybrid 1,3,4‐thiadiazole‐1,3,5‐triazine Derivatives Tethered via –S– Bridge
TL;DR: Some hybrid 1,3,4‐thiadiazole‐1, 3,5‐triazine derivatives tethered via –S– bridge were synthesized and characterized with the aid of spectroscopic and elemental analysis and excellent to moderate antibacterial activity was presented by the target compounds.