M
Manuel Nogueras
Researcher at University of Jaén
Publications - 372
Citations - 4240
Manuel Nogueras is an academic researcher from University of Jaén. The author has contributed to research in topics: Hydrogen bond & Molecule. The author has an hindex of 33, co-authored 369 publications receiving 3874 citations. Previous affiliations of Manuel Nogueras include University of Granada.
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Journal ArticleDOI
Synthesis of novel pyrazolic analogues of chalcones and their 3-aryl-4-(3-aryl-4,5-dihydro-1H-pyrazol-5-yl)-1-phenyl-1H-pyrazole derivatives as potential antitumor agents
Braulio Insuasty,Alexis Tigreros,Fabian Orozco,Jairo Quiroga,Rodrigo Abonia,Manuel Nogueras,Adolfo Sánchez,Justo Cobo +7 more
TL;DR: Several novel compounds synthesized from a Claisen-Schmidt reaction of 3-aryl-1-phenylpyrazol-4-carboxaldehydes 4 with several acetophenone derivatives were screened by the US National Cancer Institute for their ability to inhibit 60 different human tumor cell lines.
Journal ArticleDOI
Synthesis and antifungal activity of (Z)-5-arylidenerhodanines
Maximiliano Sortino,Paula Delgado,Sabina Juárez,Jairo Quiroga,Rodrigo Abonia,Braulio Insuasty,Manuel Nogueras,Laura Rodero,Francisco Matías Garibotto,Ricardo D. Enriz,Susana Zacchino +10 more
TL;DR: An efficient microwave-assisted synthesis of new (Z)-5-arylidenerhodanines under solvent-free conditions is described and their in vitro antifungal activity was evaluated following the CLSI guidelines against a panel of both standardized and clinical opportunistic pathogenic fungi.
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Isolation and identification of radical scavengers in olive tree (Olea europaea) wood.
Mercedes Pérez-Bonilla,Sofía Salido,Teris A. van Beek,Pablo J. Linares-Palomino,Joaquín Altarejos,Manuel Nogueras,Adolfo Sánchez +6 more
TL;DR: Several extracts of Olea europaea wood (Picual olive cultivar) were obtained with solvents of different polarity and their antioxidant activities determined and hydroxytyrosol showed a higher activity than the natural antioxidant rosmarinic acid in scavenging the DPPH model radical.
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Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity.
Rodrigo Abonia,Daniel Insuasty,Juan C. Castillo,Braulio Insuasty,Jairo Quiroga,Manuel Nogueras,Justo Cobo +6 more
TL;DR: Novel quinoline-2-one based chalcones were synthesized from a Claisen-Schmidt condensation by using the couple KOH/1,4-dioxane as reaction medium and may possibly be used as lead compound for developing new anticancer agents.
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Synthesis of novel analogs of 2-pyrazoline obtained from [(7-chloroquinolin-4-yl)amino]chalcones and hydrazine as potential antitumor and antimalarial agents.
Braulio Insuasty,Alba Montoya,Diana Becerra,Jairo Quiroga,Rodrigo Abonia,Sara M. Robledo,Iván D. Vélez,Yulieth Upegui,Manuel Nogueras,Justo Cobo +9 more
TL;DR: A new series of N-acetyl and N-formyl-pyrazoline derivatives 6 and 7-8 showed remarkable antitumor activity against cancer cell lines, with the most important GI50 values ranging from 0.13 to 0.99 μM.