Manuel Osorio

TL;DR: The data unveil multiple pathways by which P. gingivalis may orchestrate chronic inflammation, providing insights into interventional strategies, and identifies immune cell-dependent mechanisms whereby bacterial challenge drives persistent destructive inflammation.

TL;DR: Data indicate that during infection, Campylobacter triggers an innate inflammatory response through increased production of IL-1β,IL-6, IL-8, and TNF-α and initiates a Th1-polarized adaptive immune response as predicted from the high level of production ofIL-12.

TL;DR: It is demonstrated that both mouse peritoneal macrophages and human dendritic cells exhibited significant intracellular bactericidal activity during the first hours following uptake, providing the necessary time to mount a cytokine response prior to cell lysis.

TL;DR: The enhanced heat stability of theTy21a oral vaccine, or Ty21a derivatives expressing foreign antigens (e.g. anthrax), could mitigate risks of vaccine potency loss during long-term storage, shipping, delivery to geographical areas with warmer climates or during emergency distribution following a bioterrorist attack.

TL;DR: The ultimate goal is a temperature-stable, safe, oral human vaccine against anthrax infection that can be self-administered in a few doses over a short period of time.