M
Manuela M. Pereira
Researcher at Universidade Nova de Lisboa
Publications - 96
Citations - 3555
Manuela M. Pereira is an academic researcher from Universidade Nova de Lisboa. The author has contributed to research in topics: Respiratory chain & Oxidoreductase. The author has an hindex of 31, co-authored 90 publications receiving 3258 citations. Previous affiliations of Manuela M. Pereira include University of Helsinki & University of Lisbon.
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Molecular and biochemical characterization of a highly stable bacterial laccase that occurs as a structural component of the Bacillus subtilis endospore coat.
Lígia O. Martins,Lígia O. Martins,Cláudio M. Soares,Manuela M. Pereira,Miguel Teixeira,Teresa Costa,George H. Jones,Adriano O. Henriques +7 more
TL;DR: This model of CotA contains all the structural features of a laccase, including the reactive surface-exposed copper center (T1) and two buried copper centers (T2 and T3), and shows a half-life of inactivation at 80 °C of about 4 and 2 h, indicating that CotA is intrinsically highly thermostable.
Journal ArticleDOI
A novel scenario for the evolution of haem-copper oxygen reductases.
TL;DR: It is proposed that the Archaea domain acquired terminal oxidases by gene transfer from the Gram-positive bacteria, implying that these enzymes were not present in the last common ancestor before the divergence between Archaea and Bacteria.
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Copper incorporation into recombinant CotA laccase from Bacillus subtilis: characterization of fully copper loaded enzymes.
Paulo Durão,Zhenjia Chen,André T. Fernandes,Peter Hildebrandt,Daniel H. Murgida,Smilja Todorovic,Manuela M. Pereira,Eduardo P. Melo,Eduardo P. Melo,Lígia O. Martins +9 more
TL;DR: EPR and resonance Raman data indicate that, presumably, folding in the presence of copper is indispensable for the correct structure of the trinuclear copper-containing site.
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The superfamily of heme-copper oxygen reductases: types and evolutionary considerations.
Filipa L. Sousa,Renato J. Alves,Miguel A. Ribeiro,José B. Pereira-Leal,Miguel Teixeira,Manuela M. Pereira +5 more
TL;DR: It is observed that HCOs are widely distributed in the two prokaryotic domains and that the different types of enzymes are not confined to a specific taxonomic group or environmental niche.
Journal ArticleDOI
Structural and functional insights into sulfide:quinone oxidoreductase.
José A. Brito,Filipa L. Sousa,Meike Stelter,Tiago M. Bandeiras,Clemens Vonrhein,Miguel Teixeira,Manuela M. Pereira,Margarida Archer +7 more
TL;DR: A sulfide:quinone oxidoreductase (SQR) was isolated from the membranes of the hyperthermoacidophilic archaeon Acidianus ambivalens, and its X-ray structure revealed the presence of a chain of three sulfur atoms bridging those two cysteine residues.