Manuela Wissler

TL;DR: Clonal marking data demonstrating a rapid but unsustained contribution of cultured human autografts to the initial phase of hematologic recovery in myeloablated patients is presented.

TL;DR: Results indicate that stromal progenitor cells are present in human cytokine-mobilized peripheral blood or cord blood that engraft in NOD/SCID mice.

TL;DR: Using LAM‐PCR, the previously unfeasible in vivo retro‐, lenti‐ and foamyvirus integration site analysis in primate peripheral blood hematopoietic cells and human xenograft hematoiesis is shown.

TL;DR: It is demonstrated that a phosphorylation‐deficient mutant, TIP60S90A, exhibits reduced interaction with chromatin, histone 3 and RNA Pol II, while its association with the Tip60 complex subunit EPC1 is not affected, and it is shown that cells expressing TIP 60S 90A, but also TIP80S86A, which retains S90 phosphorylated, exhibit reduced histone 4 acetylation and proliferation.

TL;DR: The suppression of GSK-3 is the key function of PI3K signaling in order to prevent the induction of Puma by FOXO3A and p53 and thereby apoptosis upon growth factor withdrawal.