M
Manuela Wissler
Researcher at University of Freiburg
Publications - 22
Citations - 5049
Manuela Wissler is an academic researcher from University of Freiburg. The author has contributed to research in topics: Severe combined immunodeficiency & Genetic enhancement. The author has an hindex of 13, co-authored 21 publications receiving 4811 citations. Previous affiliations of Manuela Wissler include National Institutes of Health & University of Washington.
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Journal ArticleDOI
Clonality analysis after retroviral-mediated gene transfer to CD34+ cells from the cord blood of ADA-deficient SCID neonates.
Manfred Schmidt,Denise A. Carbonaro,Carsten Speckmann,Manuela Wissler,John F. Bohnsack,Melissa E. Elder,Bruce J. Aronow,Jan A. Nolta,Donald B. Kohn,Christof von Kalle,Christof von Kalle +10 more
TL;DR: T-cell clones with the predominant integrant, isolated after eight years, showed multiple patterns of T-cell receptor (TCR) gene rearrangement, indicating that a single pre-thymic stem or progenitor cell served as the source of the majority of the gene-marked cells over an extended period of time.
Journal ArticleDOI
Comparison of three retroviral vector systems for transduction of nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34+ cord blood cells.
Cordula Leurs,Michael Jansen,Michael Jansen,Karen E. Pollok,Martin Heinkelein,Manfred Schmidt,Manuela Wissler,Dirk Lindemann,Christof von Kalle,Axel Rethwilm,David R. Williams,David R. Williams,Helmut Hanenberg +12 more
TL;DR: It is shown by comparison of identically designed vector constructs that recombinant retroviral vectors based on FVs were as efficient as lentiviral vectors in transducing nonobese diabetic/severe combined immunodeficiency mice repopulating human CD34(+) cord blood (CB) cells.
Journal ArticleDOI
Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53
Céline Charvet,Manuela Wissler,Prisca Brauns-Schubert,Shang-Jui Wang,Yi Tang,Florian Christoph Sigloch,Hestia Mellert,Martin Brandenburg,Silke E. Lindner,Bernhard Breit,Douglas R. Green,Steven B. McMahon,Christoph Borner,Wei Gu,Ulrich Maurer +14 more
TL;DR: The data suggest that GSK-3 mediated Tip60S86 phosphorylation provides a link between PI3K signaling and the choice for or against apoptosis induction by p53, and is required for the p53-mediated induction of the proapoptotic BH3 only-protein PUMA.
Journal ArticleDOI
SPATA2 promotes CYLD activity and regulates TNF-induced NF-κB signaling and cell death.
Lisa Schlicher,Manuela Wissler,Florian Preiss,Prisca Brauns-Schubert,Celia Jakob,Verónica I. Dumit,Christoph Borner,Joern Dengjel,Ulrich Maurer +8 more
TL;DR: This study identifies SPATA2 as an important factor in the TNF signaling pathway with a substantial role for the effects mediated by the cytokine.
Journal ArticleDOI
Clonal evidence for the transduction of CD34+ cells with lymphomyeloid differentiation potential and self-renewal capacity in the SCID-X1 gene therapy trial.
Manfred G. Schmidt,Salima Hacein-Bey-Abina,Manuela Wissler,Frédérique Carlier,Annick Lim,Claudia Prinz,Hanno Glimm,Isabelle André-Schmutz,Christophe Hue,Alexandrine Garrigue,Françoise Le Deist,Chantal Lagresle,Alain Fischer,Marina Cavazzana-Calvo,Christof von Kalle +14 more
TL;DR: These results provide a first evidence in the setting of a clinical trial that CD34+ cells maintain both lymphomyeloid potential as well as self-renewal capacity after ex vivo manipulation.