M
Manuela Wissler
Researcher at University of Freiburg
Publications - 22
Citations - 5049
Manuela Wissler is an academic researcher from University of Freiburg. The author has contributed to research in topics: Severe combined immunodeficiency & Genetic enhancement. The author has an hindex of 13, co-authored 21 publications receiving 4811 citations. Previous affiliations of Manuela Wissler include National Institutes of Health & University of Washington.
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Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.
Silke E. Lindner,Manuela Wissler,A Gründer,Konrad Aumann,Eleonora Ottina,Lukas Peintner,Prisca Brauns-Schubert,Florian Preiss,Sebastian Herzog,Christoph Borner,C Charvet,Andreas Villunger,Heike L. Pahl,Ulrich Maurer +13 more
TL;DR: The data demonstrate that the absence of MCL-1 S159 phosphorylation provides a survival advantage for hematopoietic cells in vivo and facilitates oncogenesis.
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CD4+ T cells require Ikaros to inhibit their differentiation toward a pathogenic cell fate.
Chiara Bernardi,Gaëtan Maurer,Tao Ye,Patricia Marchal,Bernard Jost,Manuela Wissler,Ulrich Maurer,Philippe Kastner,Susan Chan,Céline Charvet +9 more
TL;DR: In this article, the authors investigated how the Ikaros transcription factor regulates the global gene expression and chromatin accessibility changes in murine T cells during Th17 polarization and after activation via the T cell receptor (TCR) and CD28.
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706. Retrovirus integration site distribution in long-term gene-corrected hematopoiesis of the SCID-X1 gene therapy clinical trial
Manfred G. Schmidt,Jingjong Hu,Salima Hacein-Bey-Abina,Alain Fischer,Manuela Wissler,Claudia Prinz,Hanno Glimm,Kerstin Schwarzwaelder,Francoise LeDeist,Alexandrine Garrigue,Isabelle André-Schmutz,Marina Cavazzana-Calvo,Christof von Kalle +12 more
TL;DR: It is concluded that the distribution of retrovirus integration sites can be assessed by random sampling in a clinical trial setting and may differ significantly from previously published assumptions, especially in settings of selective advantage related to transgene expression.
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SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD.
Laura Griewahn,Madeleine Müller,Lukas Peintner,Manuela Wissler,Martina Weiss,Prisca Brauns-Schubert,Ramin Massoumi,Christoph Borner,Olaf Gross,Monica Yabal,Céline Charvet,Ulrich Maurer +11 more
TL;DR: In this paper , the authors show that SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYld with the linear ubiquitylation assembly complex (LUBAC) component HOIP.
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Myeloid Expansion after Insertional Activation of MDS1/EVI1, PRDM16 and SETBP1 in a Successful Chronic Granulomatous Gene Therapy Trial.
Kerstin Schwarzwaelder,Manfred Schmidt,Marion Ott,Stefan Stein,Hanno Glimm,Annette Deichmann,Marlene Fischer,Claudia R. Ball,Ingo H. Pilz,Sonja Schmidt,Claudia Prinz,Sylvia Fessler,Manuela Wissler,Silke Klingenberg,Dieter Hoelzer,Reinhard Seger,Manuel Grez,Christof von Kalle +17 more
TL;DR: The data indicate that the therapeutic benefit in this trial was activated through insertional side effects, therefore the findings have important implications in novel gene therapy approaches.