Manus J.P. Biggs

TL;DR: This review focuses on the recent developments concerning the role of nanoscale structures on integrin-mediated adhesion and cellular function with an emphasis on the generation of medical constructs with regenerative applications.

TL;DR: This review will focus on biological and physicomechanical considerations currently being explored in bone tissue engineering.

TL;DR: Nanotopography is examined as a means to guide differentiation, and its application is described in the context of different subsets of stem cells, with a particular focus on skeletal (mesenchymal) stem cells.

TL;DR: The physiochemical characteristics of a material with in vivo applications are critical for the clinical success of the implant and regulate both cellular adhesion and differentiated cellular function and the effects of nanoscale pits and grooves on focal adhesion formation in human osteoblasts and the ERK/MAPK signalling pathway in mesenchymal populations are investigated.

TL;DR: This study implicates nanotopographical modification as a significant modulator of osteoblast adhesion and cellular function in mesenchymal populations.