Showing papers in "Advanced Drug Delivery Reviews in 2015"

TL;DR: An overview of the miRNA pathway, including biogenesis routes, biological roles, and clinical approaches is presented, including clinical diagnostics and therapeutic targets.

TL;DR: The background of the E PR effect, heterogeneity of this effect, physiological and pathological factors affecting the effect, the EPR effect in metastatic tumors, artifacts of theEPR effect with micellar and liposomal drugs, problems of macromolecular drug stability and drug release, and access to target sites are described.

TL;DR: The majority of intracellular oligonucleotide distribution following systemic or local administration occurs rapidly in just a few hours following administration and is facilitated by rapid endocytotic uptake mechanisms, further understanding of the intrACEllular trafficking of oligon nucleotides may provide further enhancements in design and ultimate potency of antisense oligonucotides in the future.

TL;DR: Recent efforts have advanced Raman spectroscopy to the point where the diagnostic accuracy and speed are compatible with clinical use, and an overview of various applications is provided.

TL;DR: In this paper, the authors review strategies and technologies to engineer metal surfaces to promote osseointegration with the host tissue and discuss strategies for modifying implants for cell adhesion and bone growth via integrin signaling and growth factor and cytokine delivery for bone defect repair.

TL;DR: This review discusses the key challenges to the development of the carriers for miRNA-based therapy and explores current strategies to systemically deliver miRNAs to cancer without induction of toxicity.

TL;DR: This review describes and critically assess the current strategies for enhancing tendon repair by biological means, mainly of applying growth factors, stem cells, natural biomaterials and genes, alone or in combination, to the site of tendon damage.

TL;DR: This review summarises all the events occurring after nerve damage at the level of the cell body, the site of injury and the target organ.

TL;DR: The development of siRNAs as therapeutic agents from early design to clinical trial is reviewed, with special emphasis on the development of EphA2-targeting si RNAs for ovarian cancer treatment.

TL;DR: This review will focus on biological and physicomechanical considerations currently being explored in bone tissue engineering.

TL;DR: This review highlights the current studies that focus on the identification of circulating miRNA-based diagnostic and prognostic markers, for the most prevalent types of cancer.

TL;DR: Various approaches for drug-likeness evaluations are summarized, including simple rules/filters based on molecular properties/structures and quantitative prediction models based on sophisticated machine learning methods, and a comprehensive review of recent advances is provided.

TL;DR: The vicious circle of adaptive evolution of the persisting bacteria imposes important therapeutic challenges and requires development of new drug delivery systems able to reach the different niches occupied by the bacteria in the lung of cystic fibrosis patients.

TL;DR: There has been a recent revival of interest in the use of antisense oligonucleotides to treat several neurodegenerative disorders using different approaches to prevent disease onset or halt disease progression and the first clinical trials for spinal muscular atrophy and amyotrophic lateral sclerosis showing promising results.

TL;DR: Recent studies in the field of lncRNA biology focusing mostly on mammalian species are reviewed and their therapeutic implications are discussed.

TL;DR: The main emphasis of this work is on important aspects of applying Raman spectroscopy for the detection of bacteria like sample preparation and the identification process.

TL;DR: Advances in cell and molecular therapy, including mobilisation and activation of endogenous progenitor cells, progenitors cell homing, and targeted delivery of cells, genes, or bioactive factors are discussed are discussed.

TL;DR: Established and novel extracellular signaling factors associated with various stages of fracture healing that could be targeted to promote enhanced bone regeneration are reviewed.

TL;DR: This review presents concise accounts of various conventional and emerging Raman instrumentations including associated hyphenated tools of pharmaceutical interest, relevant application cases of Raman spectroscopy in early and late phase pharmaceutical development, process analysis and micro-structural analysis of drug delivery systems.

TL;DR: A comprehensive coverage of the enormous amount of published data was not possible, so emphasis has been put on strategies that have proven to be effective in animal models of important human diseases and on examples taken from the authors' own expertise.

TL;DR: An overview of various designs employed to construct MSN-based controlled release systems and advances in the synthesis of mechanized theranostic nanoparticles open up the possibility to start envisioning future needs for medical equipment.

TL;DR: After introducing the role of growth factors during the bone regeneration process, this review exposes different issues that growth factor-based therapies have encountered in the clinic and highlights recent delivery approaches based on the natural interaction between growth factor and the ECM.

TL;DR: Stem cells can be considered as tunable pharmacological storehouses useful for combinatorial drug manufacture and delivery and shown great potential in a variety of clinical applications including the restoration of function in cardiovascular, neurodegenerative, oncologic, and genitourinary pathologies.

TL;DR: Insight is provided into the development of non-viral synthetic miRNA vectors and the promise of miRNA-based anticancer therapies, including therapeutic applications of miRNAs, challenges of vector design to overcome the delivery obstacles, and the developmentof miRNA delivery systems for cancer therapy.

TL;DR: The objective of this review is to describe the current state-of-the-art, challenges and future directions in the field of enthesis tissue engineering focusing on four key parameters: scaffold and biomaterials, cells, growth factors and mechanical stimuli.

TL;DR: In view of the fact that no new antibiotic entities against multi-drug resistant bacteria have come close to commercialisation, advanced formulation strategies are in high demand for combating respiratory 'super bugs'.

TL;DR: This review focuses on two formulation approaches, mucoadhesion and thermogelling, intended for prolonging residence time on vaginal mucosa of medical devices or drug delivery systems, thus improving their efficacy.

TL;DR: Advances in scaffolds using muscle tissue engineering are reviewed and next generation naturally derived/synthetic "hybrid materials" would combine the advantageous properties of these materials to create an optimal platform for cell/drug delivery and possess inherent bioactive properties.

TL;DR: Accumulating evidence in cancer diagnostics and therapeutics indicates that miRNAs involve in HCC progression, which may serve as sensitive biomarkers for detecting carcinogenesis and monitoring therapies of HCC.

TL;DR: Non-genetic cell engineering of cells has been applied in delivering therapeutics to tissues, homing of cells to the bone marrow or inflammatory tissues, cancer imaging, immunotherapy, and remotely controlling cellular functions.