M
Marc Ittah
Researcher at University of Paris-Sud
Publications - 17
Citations - 2262
Marc Ittah is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: B-cell activating factor & Interferon. The author has an hindex of 16, co-authored 17 publications receiving 2109 citations.
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Journal ArticleDOI
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome
Jacques-Eric Gottenberg,Nicolas Cagnard,Carlo Lucchesi,Franck Letourneur,Sylvie Mistou,Thierry Lazure,Sébastien Jacques,Nathalie Ba,Marc Ittah,Christine Lepajolec,Marc Labetoulle,M. Ardizzone,Jean Sibilia,Catherine Fournier,Gilles Chiocchia,Xavier Mariette +15 more
TL;DR: The results support the pathogenic interaction between the innate and adaptive immune system in pSS, and the persistence of the IFN signature might be related to a vicious circle, in which the environment interacts with genetic factors to drive the stimulation of salivary TLRs.
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Tolerance and efficacy of rituximab and changes in serum B cell biomarkers in patients with systemic complications of primary Sjögren’s syndrome
Raphaèle Seror,Christelle Sordet,Loïc Guillevin,Eric Hachulla,Charles Masson,Marc Ittah,Sophie Candon,Véronique Le Guern,Achille Aouba,Jean Sibilia,Jacques-Eric Gottenberg,Xavier Mariette +11 more
TL;DR: Good efficacy and fair tolerance of rituximab for systemic symptoms in patients with primary Sjögren’s syndrome are shown, and RTX allows for a marked reduction in corticosteroid use.
Journal ArticleDOI
B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome.
Marc Ittah,Corinne Miceli-Richard,Jacques-Eric Gottenberg,Frédéric Lavie,Thierry Lazure,Nathalie Ba,Jérémie Sellam,Christine Lepajolec,Xavier Mariette +8 more
TL;DR: Demonstrating the capacity of SGECs to express and secrete BAFF after IFN stimulation adds further information to the pivotal role of these epithelial cells in the pathogenesis of pSS, possibly after stimulation by innate immunity.
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Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity
Jérémie Sellam,Valérie Proulle,Astrid Jüngel,Marc Ittah,Corinne Miceli Richard,Jacques-Eric Gottenberg,Florence Toti,Joelle Benessiano,Jean-Marie Freyssinet,Xavier Mariette +9 more
TL;DR: Plasma MP level is elevated in primary Sjögren's syndrome, as well as in SLE and RA, and could be used as a biomarker reflecting systemic cell activation, and increase of platelet-derived MPs, sCD40L and sCD62P, highlights platelet activation in pSS.
Journal ArticleDOI
Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production
Frédéric Lavie,Corinne Miceli-Richard,Marc Ittah,Jérémie Sellam,Jacques-Eric Gottenberg,Xavier Mariette +5 more
TL;DR: Two distinct mechanisms are probably involved in the increase in BAFF level after B cell depletion: (1) the decrease in its receptors leading to a release of BAFF; (2) a delayed regulation of BAff mRNA transcription.