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Astrid Jüngel
Researcher at University of Zurich
Publications - 77
Citations - 5584
Astrid Jüngel is an academic researcher from University of Zurich. The author has contributed to research in topics: Synovial membrane & Fibrosis. The author has an hindex of 39, co-authored 76 publications receiving 5015 citations.
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Journal ArticleDOI
MicroRNA-29, a key regulator of collagen expression in systemic sclerosis.
Britta Maurer,Joanna Stanczyk,Astrid Jüngel,Alfiya Akhmetshina,Michelle Trenkmann,Matthias Brock,Otylia Kowal-Bielecka,Beat A. Michel,Jörg H W Distler,Oliver Distler +9 more
TL;DR: The expression of miR-29a was strongly down-regulated in SSc fibroblasts and skin sections as compared with the healthy controls and is suggested as a potential therapeutic target by researchers investigating the role of microRNA as posttranscriptional regulators of profibrotic genes in systemic sclerosis.
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Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
Jörg H W Distler,Astrid Jüngel,Lars C. Huber,Ursula Schulze-Horsel,Jochen Zwerina,Beat A. Michel,Thomas H. Hauser,Georg Schett,Oliver Distler +8 more
TL;DR: Data show that imatinib mesylate at biologically relevant concentrations has potent antifibrotic effects in vitro and in vivo, without toxic side effects, and is a promising candidate for the treatment of fibrotic diseases such as SSc.
Journal ArticleDOI
The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles
Jörg H W Distler,Astrid Jüngel,Lars C. Huber,CA Seemayer,Charles F. Reich,Beat A. Michel,Adriano Fontana,David S. Pisetsky,Oliver Distler +8 more
TL;DR: Evidence is provided for a novel mechanism by which vesicles derived from activated or apoptotic immune cells can promote the destructive activity of synovial fibroblasts in rheumatoid arthritis.
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Platelet-derived serotonin links vascular disease and tissue fibrosis
Clara Dees,Alfiya Akhmetshina,Pawel Zerr,Nicole Reich,Katrin Palumbo,Angelika Horn,Astrid Jüngel,Christian Beyer,Gerhard Krönke,Jochen Zwerina,Rudolf Reiter,Natalia Alenina,Luc Maroteaux,Georg Schett,Oliver Distler,Jörg H W Distler +15 more
TL;DR: Blocking 5-HT2B receptor provides a therapeutic target for fibrotic diseases caused by activated platelet release of serotonin during vascular damage.
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Increased levels of circulating microparticles in primary Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis and relation with disease activity
Jérémie Sellam,Valérie Proulle,Astrid Jüngel,Marc Ittah,Corinne Miceli Richard,Jacques-Eric Gottenberg,Florence Toti,Joelle Benessiano,Jean-Marie Freyssinet,Xavier Mariette +9 more
TL;DR: Plasma MP level is elevated in primary Sjögren's syndrome, as well as in SLE and RA, and could be used as a biomarker reflecting systemic cell activation, and increase of platelet-derived MPs, sCD40L and sCD62P, highlights platelet activation in pSS.