T
Thierry Lazure
Researcher at University of Paris-Sud
Publications - 82
Citations - 2240
Thierry Lazure is an academic researcher from University of Paris-Sud. The author has contributed to research in topics: Lymphoma & Medicine. The author has an hindex of 18, co-authored 75 publications receiving 1976 citations. Previous affiliations of Thierry Lazure include French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome
Jacques-Eric Gottenberg,Nicolas Cagnard,Carlo Lucchesi,Franck Letourneur,Sylvie Mistou,Thierry Lazure,Sébastien Jacques,Nathalie Ba,Marc Ittah,Christine Lepajolec,Marc Labetoulle,M. Ardizzone,Jean Sibilia,Catherine Fournier,Gilles Chiocchia,Xavier Mariette +15 more
TL;DR: The results support the pathogenic interaction between the innate and adaptive immune system in pSS, and the persistence of the IFN signature might be related to a vicious circle, in which the environment interacts with genetic factors to drive the stimulation of salivary TLRs.
Journal ArticleDOI
B cell-activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome.
Marc Ittah,Corinne Miceli-Richard,Jacques-Eric Gottenberg,Frédéric Lavie,Thierry Lazure,Nathalie Ba,Jérémie Sellam,Christine Lepajolec,Xavier Mariette +8 more
TL;DR: Demonstrating the capacity of SGECs to express and secrete BAFF after IFN stimulation adds further information to the pivotal role of these epithelial cells in the pathogenesis of pSS, possibly after stimulation by innate immunity.
Journal ArticleDOI
Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection
Abderaouf Damouche,Thierry Lazure,Véronique Avettand-Fenoel,Nicolas Huot,Nathalie Dejucq-Rainsford,Anne-Pascale Satie,Adeline Mélard,Ludivine David,Céline Gommet,Jade Ghosn,Nicolas Noel,Guillaume Pourcher,Valérie Martinez,Stéphane Benoist,Véronique Béréziat,Antonio Cosma,Benoit Favier,Bruno Vaslin,Christine Rouzioux,Jacqueline Capeau,Michaela Müller-Trutwin,Nathalie Dereuddre-Bosquet,Roger Le Grand,Olivier Lambotte,Christine Bourgeois +24 more
TL;DR: Adipose tissue is identified as a crucial cofactor in both viral persistence and chronic immune activation/inflammation during HIV infection and opens up new therapeutic strategies for limiting the size of the viral reservoir and decreasing low-grade chronic inflammation via the modulation of adipose tissue-related pathways.
Journal ArticleDOI
Immunoglobulin gene analysis reveals 2 distinct cells of origin for EBV-positive and EBV-negative Burkitt lymphomas
Cristiana Bellan,Stefano Lazzi,Michael Hummel,Nazzareno Palummo,Margherita de Santi,Teresa Amato,Joshua Nyagol,Elena Sabattini,Thierry Lazure,Stefano Pileri,Martine Raphael,Harald Stein,Piero Tosi,Lorenzo Leoncini +13 more
TL;DR: According to the molecular results, EBV-positive andEBV-negative BL may originate from 2 distinct subsets of B cells, pointing to a particular role for the germinal-center reaction in the pathogenesis of these tumors.
Journal ArticleDOI
Cytometry by time-of-flight immunophenotyping identifies a blood Sjögren's signature correlating with disease activity and glandular inflammation
Michael Mingueneau,Saida Boudaoud,Saida Boudaoud,Scott Haskett,Taylor L. Reynolds,Gaetane Nocturne,Gaetane Nocturne,Elizabeth Norton,Xueli Zhang,Myrtha Constant,Daniel J. Park,Wenting Wang,Thierry Lazure,Thierry Lazure,Christine Le Pajolec,Ayla Ergun,Xavier Mariette,Xavier Mariette +17 more
TL;DR: This first application of mass cytometry to a well-stratified clinical cohort and small biopsy tissues establishes the benefits of such an approach for the discovery of new biomarkers and therapeutic targets in patients with Primary Sjögren's syndrome.