S
Sébastien Jacques
Researcher at University of Paris
Publications - 50
Citations - 1665
Sébastien Jacques is an academic researcher from University of Paris. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 19, co-authored 41 publications receiving 1398 citations. Previous affiliations of Sébastien Jacques include Paris Descartes University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Activation of IFN pathways and plasmacytoid dendritic cell recruitment in target organs of primary Sjögren’s syndrome
Jacques-Eric Gottenberg,Nicolas Cagnard,Carlo Lucchesi,Franck Letourneur,Sylvie Mistou,Thierry Lazure,Sébastien Jacques,Nathalie Ba,Marc Ittah,Christine Lepajolec,Marc Labetoulle,M. Ardizzone,Jean Sibilia,Catherine Fournier,Gilles Chiocchia,Xavier Mariette +15 more
TL;DR: The results support the pathogenic interaction between the innate and adaptive immune system in pSS, and the persistence of the IFN signature might be related to a vicious circle, in which the environment interacts with genetic factors to drive the stimulation of salivary TLRs.
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A genome-wide approach reveals novel imprinted genes expressed in the human placenta
Sandrine Barbaux,Géraldine Gascoin-Lachambre,Christophe Buffat,Paul Monnier,Françoise Mondon,Marie-Béatrice Tonanny,Amélie Pinard,Jana Auer,Bettina Bessières,Anne Barlier,Sébastien Jacques,Umberto Simeoni,Luisa Dandolo,Franck Letourneur,Hélène Jammes,Daniel Vaiman +15 more
TL;DR: The number of known imprinted genes in humans is increased by about 10% using a high-throughput strategy by diverting the classical use of genotyping microarrays to compare the genotypes of mRNA/cDNA vs. genomic DNA to identify new genes presenting monoallelic expression, starting from human placental material.
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Combined hepatocellular-cholangiocarcinomas exhibit progenitor features and activation of Wnt and TGFβ signaling pathways
Cédric Coulouarn,Catherine Cavard,Catherine Cavard,Catherine Cavard,Laura Rubbia-Brandt,Anne Audebourg,Florent Dumont,Florent Dumont,Florent Dumont,Sébastien Jacques,Sébastien Jacques,Sébastien Jacques,Pierre-Alexandre Just,Pierre-Alexandre Just,Pierre-Alexandre Just,Bruno Clément,Hélène Gilgenkrantz,Hélène Gilgenkrantz,Hélène Gilgenkrantz,Christine Perret,Christine Perret,Christine Perret,Benoit Terris +22 more
TL;DR: It is reported that cHCC-CC exhibit stem/progenitor features, a down-regulation of the hepatocyte differentiation program and a commitment to the biliary lineage, and TGFβ and Wnt/β-catenin were identified as the two major signalling pathways activated in cH CC-CC.
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Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis.
Elena Zinovieva,Catherine Bourgain,Amir Kadi,Amir Kadi,Franck Letourneur,Franck Letourneur,Brigitte Izac,Brigitte Izac,R. Said-Nahal,Nicolas Lebrun,Nicolas Lebrun,Nicolas Cagnard,Agathe Vigier,Agathe Vigier,Sébastien Jacques,Sébastien Jacques,Corinne Miceli-Richard,Henri-Jean Garchon,Henri-Jean Garchon,Simon Heath,Céline Charon,Delphine Bacq,Anne Boland,Diana Zelenika,Gilles Chiocchia,Gilles Chiocchia,Gilles Chiocchia,Maxime Breban,Maxime Breban,Maxime Breban +29 more
TL;DR: Within the SPA2 locus a haplotype strongly associated with predisposition to SpA which is located near to TNFSF15, one of the major candidate genes in this region is identified.
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Use of Whole‐Blood Transcriptomic Profiling to Highlight Several Pathophysiologic Pathways Associated With Response to Rituximab in Patients With Rheumatoid Arthritis: Data From a Randomized, Controlled, Open‐Label Trial
Jérémie Sellam,Sandrine Marion-Thore,Florent Dumont,Sébastien Jacques,Henri-Jean Garchon,Stéphanie Rouanet,Yassine Taoufik,Houria Hendel-Chavez,Jean Sibilia,Jacques Tebib,Xavier Le Loët,Bernard Combe,Maxime Dougados,Xavier Mariette,Gilles Chiocchia +14 more
TL;DR: To identify a molecular signature that could be predictive of the clinical response to rituximab (RTX) and elucidate the transcriptomic changes after RTX therapy in patients with rheumatoid arthritis (RA), with the use of whole‐blood transcriptomic profiling.