M
Marc R. Barnard
Researcher at Boston Children's Hospital
Publications - 16
Citations - 908
Marc R. Barnard is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 10, co-authored 16 publications receiving 869 citations. Previous affiliations of Marc R. Barnard include American Red Cross & University of Massachusetts Amherst.
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Journal ArticleDOI
Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease
Mark I. Furman,Stephen E. Benoit,Marc R. Barnard,C. Robert Valeri,Marie L Borbone,Richard C. Becker,Herbert B. Hechtman,Alan D. Michelson +7 more
TL;DR: Patients with stable CAD have circulating activated platelets, circulating monocyte-platelet aggregates, increased platelet reactivity and an increased propensity to form monocytes-platelets aggregates.
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Glycoprotein Ib (GPIb)-dependent and GPIb-independent pathways of thrombin-induced platelet activation
Naomasa Yamamoto,Nicholas J. Greco,Nicholas J. Greco,Nicholas J. Greco,Marc R. Barnard,Marc R. Barnard,Marc R. Barnard,Kenjiro Tanoue,Kenjiro Tanoue,Kenjiro Tanoue,Hiroh Yamazaki,Hiroh Yamazaki,Hiroh Yamazaki,G. A. Jamieson,G. A. Jamieson,G. A. Jamieson,Alan D. Michelson,Alan D. Michelson,Alan D. Michelson +18 more
TL;DR: It is demonstrated that activation of intact platelets by alpha-thrombin proceeds by both GPIb-dependent and G PIb-independent mechanisms.
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The influence of intermittent hypoxemia on platelet activation in obese patients with obstructive sleep apnea.
Shilpa Rahangdale,Susie Yim Yeh,Victor Novack,KE Stevenson,Marc R. Barnard,Mark I. Furman,Andrew L. Frelinger,Alan D. Michelson,Atul Malhotra +8 more
TL;DR: In obese patients with OSA, platelet activation is associated with greater levels of oxygen desaturation, compared with matched control subjects, and Metrics other than AHI may determine OSA-related thrombotic risk.
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The active metabolite of prasugrel inhibits ADP-stimulated thrombo-inflammatory markers of platelet activation: Influence of other blood cells, calcium, and aspirin.
Andrew L. Frelinger,Joseph A. Jakubowski,YouFu Li,Marc R. Barnard,Marsha L. Fox,Matthew D. Linden,Atsuhiro Sugidachi,Kenneth J. Winters,Mark I. Furman,Alan D. Michelson +9 more
TL;DR: R-138727, the active metabolite of prasugrel, results in rapid, potent, consistent, and selective inhibition of P2Y12-mediated up-regulation of thromboinflammatory markers of platelet activation.
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Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.
Hung Chang,Hung Chang,Ivan B. Yanachkov,Alan D. Michelson,Alan D. Michelson,YouFu Li,Marc R. Barnard,Marc R. Barnard,George E. Wright,Andrew L. Frelinger,Andrew L. Frelinger +10 more
TL;DR: Ap(4)A, a constituent of platelet dense granules, is a) an antagonist of Platelet P2Y(1) and P2y(12) receptors, where it inhibits the effects of ADP, and b) an agonist of platelets P2X(1).