M
Marcel Hommel
Researcher at Liverpool School of Tropical Medicine
Publications - 37
Citations - 1929
Marcel Hommel is an academic researcher from Liverpool School of Tropical Medicine. The author has contributed to research in topics: Visceral leishmaniasis & Plasmodium falciparum. The author has an hindex of 21, co-authored 37 publications receiving 1859 citations. Previous affiliations of Marcel Hommel include National Institute for Medical Research.
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Parasite sequestration in Plasmodium falciparum malaria: spleen and antibody modulation of cytoadherence of infected erythrocytes
TL;DR: The results indicate that the spleen modulates the expression of parasite alterations of the infected erythrocyte membrane responsible for sequestration and suggest that the prevention and reversal of sequestration could be one of the effector mechanisms involved in antibody-mediated protection against P. falciparum malaria.
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Small, Clonally Variant Antigens Expressed on the Surface of the Plasmodium falciparum–Infected Erythrocyte Are Encoded by the rif Gene Family and Are the Target of Human Immune Responses
TL;DR: The rifins are described, the second family of clonally variant antigens known to be displayed by P. falciparum on the surface of the infected erythrocyte, and predicted polypeptides encoded by the rif multigene family are found.
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Surface alterations of erythrocytes in Plasmodium falciparum malaria. Antigenic variation, antigenic diversity, and the role of the spleen.
TL;DR: The surface of erythrocytes infected with late developmental stages of Plasmodium falciparum is profoundly altered and new antigenic determinants can be detected by surface immunofluorescence using immune squirrel monkey serum, which shows that the passive transfer of immune serum can induce antigenic variation and this can occur in a cloned parasite.
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Latex agglutination test for the detection of urinary antigens in visceral leishmaniasis
Zamil J Attar,Michael L. Chance,Sayda El-Safi,James Carney,Ahmed A. Azazy,Maha El-Hadi,Cibele Dourado,Marcel Hommel +7 more
TL;DR: Compared to microscopy, KATEX performed better than any single serological test in predicting positivity and a particularly good result was obtained by combining KATEx and the direct agglutination test (DAT).
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Alternative polymerase chain reaction method to identify Plasmodium species in human blood samples: the semi-nested multiplex malaria PCR (SnM-PCR).
TL;DR: The SnM-PCR technique worked better with samples collected in the field as dried blood spots on filter paper and heparinized blood rather than with frozen pelleted blood; it was more sensitive and more specific than the standard microscopical examination.