Marcela Savoldi

TL;DR: To increase the frequency of homologous recombination, the KU80 homologue in Aspergillus fumigatus was inactivated and deletion had no influence on pathogenicity in a low-dose murine infection model.

TL;DR: The results suggest the possible conservation of pathogenicity and virulence mechanisms among fungi, expand considerably gene identification in P. brasiliensis, and provide a broader basis for further progress in understanding its biological peculiarities.

TL;DR: This work characterized an Aspergillus fumigatus CRZ1 homologue, CrzA and demonstrated its mediation of cellular tolerance to increased concentrations of calcium and manganese, and linked calcineurin activity with asexual developmental induction, finding that CrZA supports appropriate developmental induction in a calcineURin and brlA‐dependent manner in both species.

TL;DR: A decreased mRNA expression of various ergosterol biosynthesis genes; increased mRNA levels of genes involved in a variety of cell functions, such as transporters, transcription factors, proteins involved in cell metabolism, and hypothetical proteins; and the involvement of the cyclic AMP-protein kinase signaling pathway in the increased expression of several of these genes.

TL;DR: It is demonstrated that CrzA can directly control the mRNA accumulation of the pmcA-C genes by binding to their promoter regions, supporting the interaction between calcineurin and the function of these transporters.