M
Marcella M. Baldewijns
Researcher at Maastricht University
Publications - 30
Citations - 1164
Marcella M. Baldewijns is an academic researcher from Maastricht University. The author has contributed to research in topics: Medicine & DNA methylation. The author has an hindex of 15, co-authored 22 publications receiving 965 citations. Previous affiliations of Marcella M. Baldewijns include Maastricht University Medical Centre & University of Antwerp.
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Journal ArticleDOI
VHL and HIF signalling in renal cell carcinogenesis
Marcella M. Baldewijns,Iris J. H van Vlodrop,Peter B. Vermeulen,Patricia M. M. B. Soetekouw,Manon van Engeland,Adriaan P. de Bruïne +5 more
TL;DR: In this paper, the authors discuss existing and novel findings about RCC carcinogenesis, with subsequent clinical implications, and suggest new targeting approaches such as inhibition of HIF-driven key metabolic enzymes and introduce new HIF targeting agents, such as histone deacetylase inhibitors, with successful anti-neoplastic effects.
Journal ArticleDOI
Analysis of Promoter CpG Island Hypermethylation in Cancer: Location, Location, Location!
Iris J. H van Vlodrop,Hanneke E.C. Niessen,Sarah Derks,Marcella M. Baldewijns,Wim Van Criekinge,James G. Herman,Manon van Engeland +6 more
TL;DR: The emerging evidence on the importance of the location of CpG dinucleotide hypermethylation in relation to gene expression and associations with clinicopathologic characteristics in cancer is discussed.
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Genetics and epigenetics of renal cell cancer.
Marcella M. Baldewijns,Iris J. H van Vlodrop,Leo J. Schouten,Patricia M. M. B. Soetekouw,Adriaan P. de Bruïne,Manon van Engeland +5 more
TL;DR: The background of RCC, knowledge on epigenetics in the process of renal tumorigenesis has been significantly increased in the last decades, and epigenetics will play an increasing role in the development of new therapeutic modalities and may deliver new prognostic and early diagnostic markers.
Journal ArticleDOI
Prognostic Significance of Gremlin1 (GREM1) Promoter CpG Island Hypermethylation in Clear Cell Renal Cell Carcinoma
Iris J. H van Vlodrop,Marcella M. Baldewijns,Kim M. Smits,Leo J. Schouten,Leander Van Neste,Wim Van Criekinge,Hendrik Van Poppel,Evelyne Lerut,Kornel E. Schuebel,Nita Ahuja,James G. Herman,Adriaan P. de Bruïne,Manon van Engeland +12 more
TL;DR: The strong correlation between GREM1 region iii promoter methylation and increased malignancy and its correlation with active angiogenesis indicates a role forGREM1 in ccRCC carcinogenesis and tumor angiogenic.
Journal ArticleDOI
High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile.
Marcella M. Baldewijns,Victor L. Thijssen,G. Van den Eynden,S. Van Laere,A M Bluekens,Tania Roskams,H. Van Poppel,A.P. de Bruine,Arjan W. Griffioen,Peter B. Vermeulen +9 more
TL;DR: Heterogeneity in angiogenic activity and vessel maturation of CC-RCC, to a large extent linked to nuclear grade, is suggested, with probable therapeutic implications.