Leander Van Neste

TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.

TL;DR: It is shown that transient exposure of cultured and primary leukemic and epithelial tumor cells to clinically relevant nanomolar doses produce an antitumor "memory" response, including inhibition of subpopulations of cancer stem-like cells.

TL;DR: It is demonstrated that inducing cellular oxidative stress by hydrogen peroxide treatment recruits DNA methyltransferase 1 (DNMT1) to damaged chromatin, forming a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing.

TL;DR: In this paper, the authors report a genome-wide mapping of DNA methylation patterns at proximal promoter regions in mouse embryonic stem (mES) cells, finding that the only marker of this group present on ∼30% of genes, many of which are silenced in mES cells.

TL;DR: The authors describe the importance of considering the genomic locations examined in determining the diagnostic or prognostic relevance of putative DNA methylation-based biomarkers.