K
Kim M. Smits
Researcher at Maastricht University
Publications - 72
Citations - 3853
Kim M. Smits is an academic researcher from Maastricht University. The author has contributed to research in topics: DNA methylation & Cancer. The author has an hindex of 29, co-authored 61 publications receiving 3240 citations. Previous affiliations of Kim M. Smits include Maastricht University Medical Centre.
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Journal ArticleDOI
Analysis of DNA methylation in cancer: location revisited
Alexander Koch,Sophie C. Joosten,Zheng Feng,Tim C. de Ruijter,Muriel X. G. Draht,Veerle Melotte,Kim M. Smits,Jürgen Veeck,James G. Herman,Leander Van Neste,Wim Van Criekinge,Tim De Meyer,Manon van Engeland +12 more
TL;DR: The authors describe the importance of considering the genomic locations examined in determining the diagnostic or prognostic relevance of putative DNA methylation-based biomarkers.
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K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Mirian Brink,Anton F.P.M. de Goeij,Matty P. Weijenberg,Guido M.J.M. Roemen,Marjolein H.F.M. Lentjes,Marco M.M. Pachen,Kim M. Smits,Adriaan P. de Bruïne,R. Alexandra Goldbohm,Piet A. van den Brandt +9 more
TL;DR: The equal distribution of K-ras mutations among cases with or without a family history of colorectal cancer argues against an important role for this mutation in familial coloreCTal cancer, and could imply that K-ra mutations are more probably involved in environmental mechanisms of colOREctal carcinogenesis.
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Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer
Sabine C. Glöckner,Mashaal Dhir,Joo Mi Yi,Kelly E. McGarvey,Leander Van Neste,Joost Louwagie,Timothy A. Chan,Wolfram Kleeberger,Wolfram Kleeberger,Adriaan P. de Bruïne,Kim M. Smits,Carolina A.J. Khalid-de Bakker,Daisy Jonkers,Reinhold W. Stockbrügger,Gerrit A. Meijer,Frank A. Oort,Christine A. Iacobuzio-Donahue,Katja Bierau,James G. Herman,Stephen B. Baylin,Manon van Engeland,Kornel E. Schuebel,Nita Ahuja +22 more
TL;DR: The potential of TFPI2 as a biomarker for the early detection of CRC using stool DNA-based assays in patients with nonmetastatic CRC and average-risk noncancer controls who were candidates for screening are explored.
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N-Myc Downstream-Regulated Gene 4 (NDRG4): A Candidate Tumor Suppressor Gene and Potential Biomarker for Colorectal Cancer
Veerle Melotte,Marjolein H.F.M. Lentjes,Sandra M. van den Bosch,Debby M.E.I. Hellebrekers,Joep P.J. de Hoon,Kim A.D. Wouters,Kathleen L.J. Daenen,Iris E. J. M. Partouns-Hendriks,Filip Stessels,Joost Louwagie,Kim M. Smits,Matty P. Weijenberg,Silvia Sanduleanu,Carolina A.J. Khalid-de Bakker,Frank A. Oort,Gerrit A. Meijer,Daisy Jonkers,James G. Herman,Adriaan P. de Bruïne,Manon van Engeland +19 more
TL;DR: N-Myc downstream-regulated gene 4 (NDRG4) is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation and is a potential biomarker for the noninvasive detection of coloreCTal cancer in stool samples.
Journal ArticleDOI
Lamin A/C is a risk biomarker in colorectal cancer.
Naomi D. Willis,Thomas R. Cox,Syed F. Rahman-Casans,Kim M. Smits,Stefan Przyborski,Piet A. van den Brandt,Manon van Engeland,Matty P. Weijenberg,Robert G. Wilson,Adriaan P. de Bruïne,Christopher J. Hutchison +10 more
TL;DR: This report directly links A-type lamin expression to tumour progression and raises the profile of LMNA from one implicated in multiple but rare genetic conditions to a gene involved in one of the commonest diseases in the Western World.