M
Marcello Pinti
Researcher at University of Modena and Reggio Emilia
Publications - 185
Citations - 13448
Marcello Pinti is an academic researcher from University of Modena and Reggio Emilia. The author has contributed to research in topics: Mitochondrion & Immune system. The author has an hindex of 46, co-authored 163 publications receiving 11592 citations. Previous affiliations of Marcello Pinti include University of Milan & National Institutes of Health.
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Journal ArticleDOI
The protease inhibitor atazanavir triggers autophagy and mitophagy in human preadipocytes
Lara Gibellini,Sara De Biasi,Marcello Pinti,Milena Nasi,Massimo Riccio,Gianluca Carnevale,Gian Maria Cavallini,Francisco J. Sala de Oyanguren,José E. O’Connor,Cristina Mussini,Anto De Pol,Andrea Cossarizza +11 more
TL;DR: Autophagy/mitophagy can be considered a mechanism triggered by ATV in SW872 preadipocytes, and at low doses, ATV promoted mitochondrial superoxide generation, whereas at high doses, it induced mitochondrial membrane depolarization.
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Mitophagy and Oxidative Stress: The Role of Aging
TL;DR: In this paper, the imbalance of the delicate equilibrium among mitophagy, reactive oxygen species (ROS) production and mitochondrial damage can start, drive, or accelerate the aging process, either in physiological aging, or in pathological age-related conditions such as Alzheimer's and Parkinson's diseases.
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Resistance of mtDNA-depleted cells to apoptosis.
Roberta Ferraresi,Leonarda Troiano,Marcello Pinti,Erika Roat,Enrico Lugli,Daniela Quaglino,Daniela Taverna,Dina Bellizzi,Giuseppe Passarino,Andrea Cossarizza +9 more
TL;DR: MMP was well maintained in ρ0 cells, and remained unchanged after adding apoptogenic agents, and did not change after treatment with molecules able to depolarize mitochondria such as valinomycin.
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LonP1 Differently Modulates Mitochondrial Function and Bioenergetics of Primary Versus Metastatic Colon Cancer Cells.
Lara Gibellini,Lorena Losi,Sara De Biasi,Milena Nasi,Domenico Lo Tartaro,Simone Pecorini,Simone Patergnani,Paolo Pinton,Anna De Gaetano,Gianluca Carnevale,Alessandra Pisciotta,Francesco Mariani,Luca Roncucci,Anna Iannone,Andrea Cossarizza,Marcello Pinti +15 more
TL;DR: Investigating the role of LonP1 in mitochondrial functions, metabolism, and epithelial–mesenchymal transition (EMT) in colon tumor cells and in metastasis found that silencing LonP 1 leads to severe mitochondrial impairment and apoptosis in colon cancer cells.
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Direct analysis of thymic function in children with Down's syndrome
Nicole Prada,Milena Nasi,Leonarda Troiano,Erika Roat,Marcello Pinti,Elisa Nemes,Enrico Lugli,Roberta Ferraresi,L. Ciacci,Davide Bertoni,Ornella Biagioni,Milena Gibertoni,Cristina Cornia,Liviana Meschiari,Elisabetta Gramazio,Mauro Mariotti,Ugo Consolo,Fiorella Balli,Andrea Cossarizza +18 more
TL;DR: The direct measure of thymic output indicates that the impairment of the organ results in a reduced production of newly generated T cells, which could suggest that cytokines able to modulateThymic function, such as interleukins, could be useful to improve the functionality of theorgan and to treat the immunodeficiency present in DS subjects.