M
Marcelo J. Kuroda
Researcher at Beth Israel Deaconess Medical Center
Publications - 49
Citations - 8469
Marcelo J. Kuroda is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Simian immunodeficiency virus & CTL*. The author has an hindex of 33, co-authored 48 publications receiving 8381 citations.
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Journal ArticleDOI
HBcAg-specific CD8 T cells play an important role in virus suppression, and acute flare-up is associated with the expansion of activated memory T cells.
Noriaki Shimada,Kazuhide Yamamoto,Marcelo J. Kuroda,Ryo Terada,Tomomi Hakoda,Hiroyuki Shimomura,Hidenori Hata,Eiichi Nakayama,Yasushi Shiratori +8 more
TL;DR: HBV-specific CD8 T cells play an important role in the suppression of virus replication, and acute flare-up is associated with the expansion and activation of HBV- specific memory cells.
Journal ArticleDOI
Human immunodeficiency virus type 1 envelope epitope-specific CD4(+) T lymphocytes in simian/human immunodeficiency virus-infected and vaccinated rhesus monkeys detected using a peptide-major histocompatibility complex class II tetramer.
Marcelo J. Kuroda,Jörn E. Schmitz,Christine Lekutis,Christine E. Nickerson,Michelle A. Lifton,Genoveffa Franchini,Janet M. Harouse,Cecilia Cheng-Mayer,Norman L. Letvin +8 more
TL;DR: Env p46-specific CD4+ T cells can be detected by tetrameric Mamu-DR*W201–p46 complex staining of PBMCs in both SHIV-infected and vaccinated rhesus monkeys.
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A Commonly Recognized Simian Immunodeficiency Virus Nef Epitope Presented to Cytotoxic T Lymphocytes of Indian-Origin Rhesus Monkeys by the Prevalent Major Histocompatibility Complex Class I Allele Mamu-A*02
Suzanne Robinson,William A. Charini,Michael H. Newberg,Marcelo J. Kuroda,Carol I. Lord,Norman L. Letvin +5 more
TL;DR: Knowing of this SIV and SHIV Nef CTL epitope and MHC class I allele substantially increases the number of available rhesus monkeys that can be used for testing prototype HIV vaccines in this important animal model.
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Functional Equivalency of B7-1 and B7-2 for Costimulating Plasmid DNA Vaccine-Elicited CTL Responses
Sampa Santra,Dan H. Barouch,Shawn S. Jackson,Marcelo J. Kuroda,Joern E. Schmitz,Michelle A. Lifton,Arlene H. Sharpe,Norman L. Letvin +7 more
TL;DR: It is demonstrated that either B7-1 or B8-2 administered concurrently with a plasmid DNA vaccine can fully costimulate vaccine-elicited CTL responses, which may not reflect inherent differences in the interactions of CD28 with these ligands.
Journal ArticleDOI
Engineered T-cell receptor tetramers bind MHC-peptide complexes with high affinity.
Ramu A. Subbramanian,Chikaya Moriya,Kristi L. Martin,Fred W. Peyerl,Atsuhiko Hasegawa,Akira Naoi,Heng Chhay,Patrick Autissier,Darci A. Gorgone,Michelle A. Lifton,Kristine Kuus-Reichel,Jörn E. Schmitz,Norman L. Letvin,Marcelo J. Kuroda +13 more
TL;DR: TCR tetramers should facilitate analysis of the MHC-peptide interface and, more generally, the design of immunotherapeutics and vaccines, and are identified in the absence of accessory molecules.