M
Márcia Susana Nunes Silva
Researcher at Universidade Luterana do Brasil
Publications - 26
Citations - 409
Márcia Susana Nunes Silva is an academic researcher from Universidade Luterana do Brasil. The author has contributed to research in topics: Mycobacterium tuberculosis & INHA. The author has an hindex of 9, co-authored 26 publications receiving 388 citations. Previous affiliations of Márcia Susana Nunes Silva include Universidade Federal do Rio Grande do Sul.
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Mutations in katG, inhA, and ahpC genes of Brazilian isoniazid-resistant isolates of Mycobacterium tuberculosis
Márcia Susana Nunes Silva,Simone Gonçalves Senna,Marta Osório Ribeiro,Andréia Rosane de Moura Valim,Maria Alice da Silva Telles,Afrânio Lineu Kritski,Glenn P. Morlock,Robert C. Cooksey,Arnaldo Zaha,Maria Lucia Rosa Rossetti +9 more
TL;DR: The presence of mutations in specific regions of the katG, inhA, and ahpC genes was analyzed with 69 Mycobacterium tuberculosis isoniazid-resistant isolates from three Brazilian states.
Journal ArticleDOI
Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America
Elis Regina Dalla Costa,Marta Osório Ribeiro,Márcia Susana Nunes Silva,Liane Silveira Arnold,Diana Rostirolla,Patrícia Izquierdo Cafrune,Roger Espinoza,Moises Palaci,Maria Alice da Silva Telles,Viviana Ritacco,Philip Noel Suffys,Maria Luiza Lopes,Creuza Campelo,Silvana Spíndola de Miranda,Kristin Kremer,Pedro Eduardo Almeida da Silva,Leila de Souza Fonseca,John L. Ho,Afranio Lineu Kritski,Maria Lucia Rosa Rossetti +19 more
TL;DR: Genetic screening for the S315T katG mutation may provide rapid information for anti-TB regimen selection, epidemiological monitoring of isoniazid (INH) resistance and, possibly, to track transmission of INH resistant strains.
Journal ArticleDOI
Resistant tuberculosis: a molecular review
Maria Lucia Rosa Rossetti,Andréia Rosane de Moura Valim,Márcia Susana Nunes Silva,Vivian de F.S. Rodrigues +3 more
TL;DR: The molecular mechanisms associated with drug-resistance as well the new perspectives for detecting resistant isolates are reviewed, which are of increasing significance for the whole global community.
Journal ArticleDOI
Direct-test PCR for detection of meningococcal DNA and its serogroup characterization: standardization and adaptation for use in a public health laboratory.
Ludmila F. Baethgen,C.G.P. Moraes,Luciana Weidlich,S. Rios,C. Í. Kmetzsch,Márcia Susana Nunes Silva,Maria Lucia Rosa Rossetti,Arnaldo Zaha +7 more
TL;DR: A direct PCR test (DT-PCR) was established to detect Neisseria meningitidis DNA in clinical samples from patients with suspected bacterial meningitis and the sensitivity was 83 % for agarose gel DNA detection and 96.4 % using dot-blot DNA detection.
Journal ArticleDOI
Colorimetric microwell plate reverse-hybridization assay for Mycobacterium tuberculosis detection.
Candice Tosi Michelon,Franciele Rosso,Karen Barros Schmid,Rosa Dea Sperhacke,Martha Maria Oliveira,Afrânio Lineu Kritski,Leonides Rezende Jr,Elis Regina Dalla Costa,Andrezza Woloski Ribeiro,Mirela Verza,Patrícia Izquierdo Cafrune,Márcia Susana Nunes Silva,Daniele Kuhleis,Arnaldo Zaha,Maria Lucia Rosa Rossetti +14 more
TL;DR: A pre-commercial colorimetric method for detecting Mycobacterium tuberculosis DNA in which an oligonucleotide probe is fixed onto wells of microwell plates and hybridized with biotinylated polymerase chain reaction amplification products derived from clinical samples showed similar specificity to that described for commercially available kits.