Marcus A. Jackson

TL;DR: In this paper, the U.S. Environmental Protection Agency's Office of Pesticide Programs (OPP) published data on a group of selected chloroacetanilides and a few related compounds.

TL;DR: Evidence accumulated to date suggests that gene expression profiles reflect underlying modes or mechanisms of action, such that they will be useful in the prediction of chemical carcinogenicity, especially in conjunction with conventional short-term tests for gene mutation, chromosomal aberration and aneuploidy.

TL;DR: Benomyl/MBC induction of aneuploidy cannot be definitively linked to mouse liver carcinogenicity at this time because of weaknesses in the data base and deficiencies in defining the MOA, which introduces uncertainties into the analysis.

TL;DR: Retinol, chlorophyllin, and N-acetylcysteine are examined and compared with regard to their antimutagenic activity against some promutagens and a group of direct-acting alkylating agents with emphasis on the xenobiotic metabolizing enzyme systems.

TL;DR: The role of short-term test data in influencing the overall classification of specific compounds in recent Monograph volumes is discussed, particularly with reference to studies in human populations, and the implications of this approach in identifying mutational mechanisms of carcinogenesis are discussed.