Marek Bodzioch

TL;DR: Evidence is presented that TD is caused by mutations in ABC1, encoding a member of the ATP-binding cassette (ABC) transporter family, located on chromosome 9q22–31, which has implications for the understanding of cellular HDL metabolism and reverse cholesterol transport, and its association with premature cardiovascular disease.

TL;DR: None of the variants were significantly associated with plasma HDL-C concentrations in either population; however, in VA-HIT, the G3456C variant was associated with a significantly increased risk for CHD end points, suggesting a role for this variant in the premature CHD observed in this population.

TL;DR: In this article, the existence of 13 mt-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides was investigated.

TL;DR: It is demonstrated here that the ATP-binding cassette (ABC) transporter ABCA1 is induced during differentiation of human monocytes into macrophages, indicating a dual regulatory function for ABCA 1 in macrophage lipid metabolism and inflammation.

TL;DR: Evidence and hypotheses about the new pathophysiological aspects of PPARs activation are reviewed and it is shown that both PPARa and PPARg activation reveal cardio-protective effect in hypertension-induced cardiac hypertrophy.