Evidence for potential functionality of nuclearly-encoded humanin isoforms
Marek Bodzioch,Katarzyna Lapicka-Bodzioch,Barbara Zapała,Wojciech Kamysz,Beata Kieć-Wilk,Aldona Dembinska-Kiec +5 more
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TLDR
In this article, the existence of 13 mt-RNR2-like nuclear loci predicted to maintain the open reading frames of 15 distinct full-length HN-like peptides was investigated.About:
This article is published in Genomics.The article was published on 2009-10-01 and is currently open access. It has received 94 citations till now. The article focuses on the topics: Humanin & Peptide sequence.read more
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Humanin: a harbinger of mitochondrial-derived peptides?
TL;DR: Humanin is discussed, the first small peptide of a putative set of mitochondrial-derived peptides (MDPs), which exhibits strong cytoprotective actions against various stress and disease models.
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Whole-transcriptome brain expression and exon-usage profiling in major depression and suicide: evidence for altered glial, endothelial and ATPase activity.
Spiro P. Pantazatos,Yung-yu Huang,Gorazd Rosoklija,Andrew J. Dwork,Victoria Arango,J. John Mann +5 more
TL;DR: Results lend further support for models in which deficits in microglial, endothelial (blood–brain barrier), ATPase activity and astrocytic cell functions contribute to MDD and suicide, and identify putative pathways and mechanisms for further study in these disorders.
Journal ArticleDOI
The emerging role of the mitochondrial-derived peptide humanin in stress resistance.
TL;DR: A review of the emerging role of humanin in stress resistance and its proposed mechanism of action discusses the potential uses and applications of the peptide.
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The mitochondrial-derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction
Parameswaran G. Sreekumar,Keijiro Ishikawa,Chris Spee,Hemal H. Mehta,Junxiang Wan,Kelvin Yen,Pinchas Cohen,Ram Kannan,David R. Hinton +8 more
TL;DR: A potential role for HN therapy in the prevention of retinal degeneration, including AMD is suggested after a prominent localization of HN was found in the cytoplasmic and mitochondrial compartments of hRPE.
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The neurosurvival factor Humanin inhibits β-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice
Phuong T. Hoang,Patricia Park,Laura J. Cobb,Valdislava Paharkova-Vatchkova,Michael Hakimi,Pinchas Cohen,Kuk-Wha Lee +6 more
TL;DR: Humanin treatment decreases cytokine-induced apoptosis in beta-cells in vitro and improved glucose tolerance and onset of diabetes in NOD mice in vivo indicates that Humanin may be useful for islet protection and survival in a spectrum of diabetes-related therapeutics.
References
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An enhanced MITOMAP with a global mtDNA mutational phylogeny.
Eduardo Ruiz-Pesini,Marie T. Lott,Vincent Procaccio,Jason C. Poole,Marty C. Brandon,Dan Mishmar,Dan Mishmar,Christina Yi,James Kreuziger,Pierre Baldi,Douglas C. Wallace +10 more
TL;DR: The MITOMAP data system for the human mitochondrial genome has been greatly enhanced by the addition of a navigable mutational mitochondrial DNA (mtDNA) phylogenetic tree of ∼3000 mtDNA coding region sequences plus expanded pathogenic mutation tables and a nuclear-mtDNA pseudogene (NUMT) data base.
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Humanin peptide suppresses apoptosis by interfering with Bax activation
Bin Guo,Dayong Zhai,Edelmira Cabezas,Kate Welsh,Shahrzad Nouraini,Arnold C. Satterthwait,John C. Reed +6 more
TL;DR: This work shows that Bax interacts with humanin (HN), an anti-apoptotic peptide of 24 amino acids encoded in mammalian genomes, providing a mechanism for protecting these organelles from Bax.
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A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ
Yuichi Hashimoto,Takako Niikura,Hirohisa Tajima,Takashi Yasukawa,Haruka Sudo,Yuko Ito,Yoshiko Kita,Masaoki Kawasumi,Keisuke Kouyama,Manabu Doyu,Gen Sobue,Takashi Koide,Shoji Tsuji,Jochen Lang,Kiyoshi Kurokawa,Ikuo Nishimoto +15 more
TL;DR: A gene is identified, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Aβ amyloid, without effect on death by Q79 or superoxide dismutase-1 mutants.
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NUMTs in Sequenced Eukaryotic Genomes
Erik Richly,Dario Leister +1 more
TL;DR: Analysis of 13 eukaryotic species with sequenced mitochondrial and nuclear genomes reveals a large interspecific variation of NUMT number and size.
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Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
Maaria Ikonen,Bingrong Liu,Yuichi Hashimoto,Liqun Ma,Kuk-Wha Lee,Takako Niikura,Ikuo Nishimoto,Pinchas Cohen +7 more
TL;DR: An interaction between the survival peptide HN and IGFBP-3 that is pleiotrophic in nature and is capable of both synergistic and antagonistic interaction is identified.