M
Margaret O. Nwagwu
Researcher at Southampton General Hospital
Publications - 3
Citations - 370
Margaret O. Nwagwu is an academic researcher from Southampton General Hospital. The author has contributed to research in topics: Low protein & Renal function. The author has an hindex of 3, co-authored 3 publications receiving 362 citations.
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Evidence of progressive deterioration of renal function in rats exposed to a maternal low-protein diet in utero.
TL;DR: Findings are suggestive of a progressive deterioration of renal function in hypertensive rats exposed to mild maternal protein restriction during fetal life, consistent with the hypothesis that adaptations to maintain renal haemodynamic functions following impairment of fetal nephrogenesis result in an accelerated progression towards glomerulosclerosis and increased intrarenal pressures mediated by rising vascular resistance.
Journal ArticleDOI
Intrauterine programming of hypertension: the role of the renin-angiotensin system.
Simon C. Langley-Evans,R.C. Sherman,Simon J. M. Welham,Margaret O. Nwagwu,David S. Gardner,Alan Jackson +5 more
TL;DR: Progress has been made in demonstrating that hypertension can be prenatally programmed through maternal dietary manipulation and some of the putative mechanisms involved have been identified, and the priorities must now be to clarify the role of maternal diet as a programming stimulus in order to generate an effective series of public health guidelines for pregnant women.
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Impaired growth and increased glucocorticoid-sensitive enzyme activities in tissues of rat fetuses exposed to maternal low protein diets
TL;DR: The data suggest that low protein exposure, particularly in late gestation is associated with increased fetal glucocorticoid-exposure, which may both retard fetal growth and programme later increases in systolic blood pressure.