M
Margaret S. Hartlage
Researcher at University of Michigan
Publications - 2
Citations - 53
Margaret S. Hartlage is an academic researcher from University of Michigan. The author has contributed to research in topics: Tumor microenvironment & Glioma. The author has an hindex of 1, co-authored 2 publications receiving 4 citations.
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Journal ArticleDOI
G-CSF secreted by mutant IDH1 glioma stem cells abolishes myeloid cell immunosuppression and enhances the efficacy of immunotherapy.
Mahmoud S. Alghamri,Brandon L. McClellan,Ruthvik Avvari,Rohit Thalla,Stephen Carney,Margaret S. Hartlage,Santiago Haase,Maria Ventosa,Ayman Taher,Neha Kamran,Li Zhang,Syed M Faisal,Felipe J Nunez,Maria B. Garcia-Fabiani,Wajd N. Al-Holou,Daniel A. Orringer,Shawn L. Hervey-Jumper,Jason Heth,Parag G. Patil,Karen Eddy,Sofia D. Merajver,Peter J. Ulintz,Joshua D. Welch,Chao Gao,Jialin Liu,Gabriel Núñez,Dolores Hambardzumyan,Pedro R. Lowenstein,Maria G. Castro +28 more
TL;DR: In this paper, the authors show that the efficacy of immune-stimulatory gene therapy (TK/Flt3L) is enhanced in mIDH1 gliomas, due to the reprogramming of the myeloid cells' compartment infiltrating the tumor microenvironment (TME).
Journal ArticleDOI
Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments.
Mahmoud S. Alghamri,Brandon L. McClellan,Margaret S. Hartlage,Santiago Haase,Syed M Faisal,Rohit Thalla,Ali Dabaja,Kaushik Banerjee,Stephen Carney,Anzar A. Mujeeb,Michael R. Olin,James J. Moon,Anna Schwendeman,Pedro R. Lowenstein,Maria G. Castro +14 more
TL;DR: Glioblastomas are one of the most lethal types of cancers accounting for ~80% of all central nervous system (CNS) primary malignancies [1, as discussed by the authors.