M
Mahmoud S. Alghamri
Researcher at University of Michigan
Publications - 37
Citations - 681
Mahmoud S. Alghamri is an academic researcher from University of Michigan. The author has contributed to research in topics: Glioma & Tumor microenvironment. The author has an hindex of 8, co-authored 28 publications receiving 338 citations. Previous affiliations of Mahmoud S. Alghamri include Wright State University.
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Journal ArticleDOI
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response.
Felipe J Nunez,Flor M. Mendez,Padma Kadiyala,Mahmoud S. Alghamri,Masha G. Savelieff,Maria B. Garcia-Fabiani,Santiago Haase,Carl Koschmann,Anda Alexandra Calinescu,Neha Kamran,Meghna Saxena,Rohin Patel,Stephen Carney,Marissa Z Guo,Marta Edwards,Mats Ljungman,Tingting Qin,Maureen A. Sartor,Rebecca Tagett,Sriram Venneti,Jacqueline A. Brosnan-Cashman,Alan K. Meeker,Vera Gorbunova,Lili Zhao,Daniel M. Kremer,Li Zhang,Costas A. Lyssiotis,Lindsey E Jones,Cameron Herting,James Ross,Dolores Hambardzumyan,Shawn L. Hervey-Jumper,Maria E. Figueroa,Maria E. Figueroa,Pedro R. Lowenstein,Maria G. Castro +35 more
TL;DR: It is discovered that IDH1R132H expression in the genetic context of ATRX and TP53 gene inactivation increases median survival in the absence of treatment, enhances DNA damage response (DDR) via epigenetic up-regulation of the ataxia-telangiectasia–mutated (ATM) signaling pathway, and elicits tumor radioresistance.
Journal ArticleDOI
Current state and future prospects of immunotherapy for glioma.
Neha Kamran,Mahmoud S. Alghamri,Felipe J Nunez,Diana Shah,Antonela Sofía Asad,Marianela Candolfi,David Altshuler,Pedro R. Lowenstein,Maria G. Castro +8 more
TL;DR: This review highlights the wide array of immunotherapeutic interventions that are currently being tested in glioma patients and indicates that combinatorial approaches targeting multiple pathways tailored to the genetic signature of the tumor will be required to achieve optimal therapeutic efficacy.
Journal ArticleDOI
Inhibition of 2-hydroxyglutarate elicits metabolic reprogramming and mutant IDH1 glioma immunity in mice
Padma Kadiyala,Stephen Carney,Jessica C. Gauss,Maria B. Garcia-Fabiani,Santiago Haase,Mahmoud S. Alghamri,Felipe J Nunez,Yayuan Liu,Minzhi Yu,Ayman Taher,Fernando M. Nunez,Dan Li,Marta Edwards,Celina G. Kleer,Henry D. Appelman,Yilun Sun,Lili Zhao,James J. Moon,Anna Schwendeman,Pedro R. Lowenstein,Maria G. Castro +20 more
TL;DR: It is demonstrated that metabolic reprogramming elicits anti-mIDH1 glioma immunity, leading to increased MS and immunological memory and the testing of IDH-R132H inhibitors in combination with IR/TMZ and anti-PDL1 as targeted therapy for mIDH 1/mATRX/mTP53 gliomas patients is supported.
Journal ArticleDOI
Adenovirus entry from the apical surface of polarized epithelia is facilitated by the host innate immune response.
Poornima L.N. Kotha,Priyanka Sharma,Abimbola O. Kolawole,Ran Yan,Mahmoud S. Alghamri,Trisha L. Brockman,Julian Gomez-Cambronero,Katherine J. D. A. Excoffon +7 more
TL;DR: In this article, the authors showed that IL-8, a proinflammatory cytokine and a neutrophil chemoattractant, stimulates the protein expression and apical localization of CAREx8 via activation of AKT/S6K and inhibition of GSK3β.
Journal ArticleDOI
Enhanced angiotensin II-induced cardiac and aortic remodeling in ACE2 knockout mice.
Mahmoud S. Alghamri,Nathan M. Weir,Mark P. Anstadt,Khalid M. Elased,Susan B. Gurley,Mariana Morris +5 more
TL;DR: Studies in the ACE2 KO model reveal the importance of ACE2 in the maladaptive cardiac and aortic responses to Ang II stimulation, seen as enhanced remodeling using physiological, structural, and biochemical markers.