M
Marge C. Lenane
Researcher at National Institutes of Health
Publications - 8
Citations - 1163
Marge C. Lenane is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Clomipramine & Desipramine. The author has an hindex of 6, co-authored 8 publications receiving 1153 citations. Previous affiliations of Marge C. Lenane include University of Maryland, Baltimore.
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Journal ArticleDOI
Childhood-onset schizophrenia: A double-blind clozapine-haloperidol comparison
Sanjiv Kumra,Jean A. Frazier,Leslie K. Jacobsen,Kathleen McKenna,Charles T. Gordon,Marge C. Lenane,Susan D. Hamburger,Amy Smith,Kathleen E. Albus,Javad Alaghband-Rad,Judith L. Rapoport +10 more
TL;DR: In this article, the efficacy and adverse effects of clozapine and haloperidol were compared for children and adolescents with early-onset schizophrenia in a 6-week double-blind parallel comparison.
Journal ArticleDOI
Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents. A double-blind crossover comparison.
Henrietta L. Leonard,Susan E. Swedo,Judith L. Rapoport,Elisabeth V. Koby,Marge C. Lenane,Deborah L. Cheslow,Susan D. Hamburger +6 more
TL;DR: A 10-week double-blind crossover trial of clomipramine hydrochloride (mean dose [+/- SD], 150 +/- 53 mg/d) and desipramines hydrochlorides (means dose = 153 +/- 55 mg/D) was conducted in this paper.
Journal Article
Treatment of obsessive-compulsive disorder with clomipramine and desipramine in children and adolescents : a double-blind crossover comparison
Henrietta L. Leonard,Susan E. Swedo,Judith L. Rapoport,Elisabeth V. Koby,Marge C. Lenane,Deborah L. Cheslow,Susan D. Hamburger +6 more
TL;DR: The specificity of the antiobsessional effect of clomipramine and the need for maintenance treatment is documented, and age at onset, duration and severity of illness, type of symptom, and plasma drug concentrations did not predict clinical response.
Journal ArticleDOI
"Multidimensionally impaired disorder": is it a variant of very early-onset schizophrenia?
Sanjiv Kumra,Leslie K. Jacobsen,Marge C. Lenane,Theodore P. Zahn,Edythe Wiggs,Javad Alaghband-Rad,F. Xavier Castellanos,Jean A. Frazier,Kathleen McKenna,Charles T. Gordon,Amy Smith,Susan D. Hamburger,Judith L. Rapoport +12 more
TL;DR: The findings support the distinction of the multidimensionally impaired cases as separate from those with other psychiatric disorders, and there is somewhat greater evidence to suggest that this disorder belongs in the schizophrenia spectrum.
An open trial of plasma exchange in childhood-onset obsessive-compulsive disorder without poststreptococcal exacerbations
Rob Nicolson,Susan E. Swedo,Marge C. Lenane,Jeffrey S. Bedwell,Marianne Wudarsky,Peter Gochman,Susan D. Hamburger,Judith L. Rapoport +7 more
TL;DR: Patients with childhood-onset obsessive-compulsive disorder (OCD) with symptom exacerbations following streptococcal infections benefit from treatment with plasma exchange, but Plasma exchange does not benefit children and adolescents with OCD who do not have strePTococcus-related exacerbations.