M
Maria Beatrice Morelli
Researcher at University of Camerino
Publications - 86
Citations - 7811
Maria Beatrice Morelli is an academic researcher from University of Camerino. The author has contributed to research in topics: Transient receptor potential channel & Cancer. The author has an hindex of 28, co-authored 74 publications receiving 6749 citations. Previous affiliations of Maria Beatrice Morelli include Sapienza University of Rome.
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Journal ArticleDOI
Coexpression of TRPML1 and TRPML2 Mucolipin Channels Affects the Survival of Glioblastoma Patients
Giorgio Santoni,Federica Maggi,Consuelo Amantini,Antonietta Arcella,Oliviero Marinelli,Massimo Nabissi,Matteo Santoni,Maria Beatrice Morelli +7 more
TL;DR: The double knockdown of TRP ML1 and TRPML2 leads to increased GBM cell survival with respect to single-channel-silenced cells, and improves migration and invasion ability of U251 cells.
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Calcium influx, oxidative stress, and apoptosis induced by TRPV1 in chronic myeloid leukemia cells: Synergistic effects with imatinib
Federica Maggi,Maria Beatrice Morelli,Cristina Aguzzi,Laura Zeppa,Massimo Nabissi,Carlo Polidori,Giorgio Santoni,Consuelo Amantini +7 more
TL;DR: In this paper , the activation of transient receptor potential vanilloid 1, by Noleoyl-dopamine, in chronic myeloid leukemia cell lines was investigated, and the activation induced calcium influx, oxidative stress, ER stress, mitochondria dysfunction, and caspase activation.
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Emerging Role of TRPML1 Mucolipin Endolysosomal Channel in Cancer
Giorgio Santoni,Matteo Santoni,Massimo Nabissi,Oliviero Marinelli,Consuelo Amantini,Maria Beatrice Morelli +5 more
TL;DR: interesting and recent data are presented suggesting for an important role played by TRPML1 in cancer, both up and down-regulation of TRP ML1 mRNA and protein expression is associated with different cancer types.
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Different effects of sunitinib, sorafenib, and pazopanib on inducing cancer cell death: The role of autophagy.
Matteo Santoni,Consuelo Amantini,Maria Beatrice Morelli,Valerio Farfariello,Massimo Nabissi,Sonia Liberati,Laura Bonfili,Matteo Mozzicafreddo,Anna Maria Eleuteri,Luciano Burattini,Rossana Berardi,Stefano Cascinu,Giorgio Santoni +12 more
TL;DR: Different TKI-induced cell death mechanisms provide the rationale for the sequential use of these agents and the biological basis for novel molecularly targeted approaches.
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Unveiling the Molecular Mechanisms Driving the Capsaicin-Induced Immunomodulatory Effects on PD-L1 Expression in Bladder and Renal Cancer Cell Lines
Maria Beatrice Morelli,Oliviero Marinelli,Cristina Aguzzi,Laura Zeppa,Massimo Nabissi,Consuelo Amantini,Daniele Tomassoni,Federica Maggi,Matteo Santoni,Giorgio Santoni +9 more
TL;DR: There is a rationale for CPS exploitation as a stimulus that increases BC cells’ response to immunotherapy or as an immune adjuvant to improve the efficacy of the conventional therapy in RCC patients, and results show that CPS mediates a multi-faceted approach.