M
Maria Beatrice Morelli
Researcher at University of Camerino
Publications - 86
Citations - 7811
Maria Beatrice Morelli is an academic researcher from University of Camerino. The author has contributed to research in topics: Transient receptor potential channel & Cancer. The author has an hindex of 28, co-authored 74 publications receiving 6749 citations. Previous affiliations of Maria Beatrice Morelli include Sapienza University of Rome.
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Isofuranodiene synergizes with temozolomide in inducing glioma cells death.
Alessandra Brunetti,Oliviero Marinelli,Maria Beatrice Morelli,Romilde Iannarelli,Consuelo Amantini,Domenico Russotti,Giorgio Santoni,Filippo Maggi,Massimo Nabissi +8 more
TL;DR: This study demonstrated the glioma selectivity of IFD and its cytotoxic properties suggesting a new strategy for the treatment of GBM in order to overcome the TMZ resistance and to reduce its side effects.
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Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells.
Consuelo Amantini,Maria Beatrice Morelli,Matteo Santoni,Alessandra Soriani,Claudio Cardinali,Valerio Farfariello,Anna Maria Eleuteri,Laura Bonfili,Matteo Mozzicafreddo,Massimo Nabissi,Stefano Cascinu,Giorgio Santoni +11 more
TL;DR: The results show that apoptotic cell death induced by sorafenib in bladder cancer cells is dependent on cathepsin B activity and involved PTEN and Akt signaling pathways.
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Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner
Maria Beatrice Morelli,Consuelo Amantini,Massimo Nabissi,Claudio Cardinali,Claudio Cardinali,Matteo Santoni,Giovanni Bernardini,Angela Santoni,Giorgio Santoni +8 more
TL;DR: It is demonstrated that the TKI axitinib induces DNA damage response (DDR) characterized by γ-H2AX phosphorylation and Chk1 kinase activation leading to G2/M cell cycle arrest and mitotic catastrophe in U87, T98 and U251 glioma cell lines, and p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death.
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Advances in transient receptor potential vanilloid-2 channel expression and function in tumor growth and progression.
Sonia Liberati,Maria Beatrice Morelli,Consuelo Amantini,Matteo Santoni,Massimo Nabissi,Claudio Cardinali,Giorgio Santoni +6 more
TL;DR: Bladder cancer tumors show loss or reduction of a short TRPV2 variant during cancer progression, with increased malignancy and invasiveness, and high expression of TRpV2 was also observed more frequently in esophageal squamous cell carcinoma patients with advanced pT stage, lymph node metastasis and advanced pathological stage.
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Involvement of the TRPML Mucolipin Channels in Viral Infections and Anti-viral Innate Immune Responses.
Giorgio Santoni,Maria Beatrice Morelli,Consuelo Amantini,Massimo Nabissi,Matteo Santoni,Angela Santoni +5 more
TL;DR: TRPML channels might play a double-edged sword in resistance to viral infections: on the other side, by regulating TLR responses in the various immune cells, they contribute to enhance antiviral innate and possibly adaptive immune responses.