Maria Constancia O. Carrillo

TL;DR: The current TB treatment, emergence of drug resistance, and the effective application of computational tools to the different stages of TB drug discovery when combined with traditional biochemical methods are discussed.

TL;DR: Computer-aided drug discovery and development approaches such as virtual screening, molecular docking, and in silico drug property calculations have been utilized in this effort to discover new lead compounds against tuberculosis, yielding 45 high-scoring, high-affinity compounds with desirable insilico absorption, distribution, metabolism, excretion, and toxicity properties.

TL;DR: Nine compounds with superior binding energies compared to its known inhibitor (decanoic acid) have been identified and may pave the way for the development of a novel class of antituberculosis agents.

TL;DR: This is the first census report of the Pasig River microbial population using an approach that utilizes 16S rDNA sequences without culture nor isolation of bacteria, and suggests an abundance of sulfur containing compounds in the riverbed.