G
Gisela P. Concepcion
Researcher at University of the Philippines Diliman
Publications - 117
Citations - 2985
Gisela P. Concepcion is an academic researcher from University of the Philippines Diliman. The author has contributed to research in topics: Conus & Conoidea. The author has an hindex of 30, co-authored 114 publications receiving 2616 citations. Previous affiliations of Gisela P. Concepcion include University of Utah & University of the Philippines.
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Journal ArticleDOI
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
Gary S. Coombs,Jia Yu,Claire A. Canning,Charles A. Veltri,Tracy M. Covey,Jit Kong Cheong,Velani Utomo,Nikhil Banerjee,Zong Hong Zhang,Raquel C. Jadulco,Gisela P. Concepcion,Tim S. Bugni,Mary Kay Harper,Ivana Mihalek,C. Michael Jones,Chris M. Ireland,David M. Virshup +16 more
TL;DR: It is proposed that WLS binds Wnts in part through a lipid-binding domain, and that vacuolar acidification is required to release palmitoylated WNT3A from WLS in secretory vesicles, possibly to facilitate transfer of Wnt3A to a soluble carrier protein.
Journal ArticleDOI
Possible Loss of the Chloroplast Genome in the Parasitic Flowering Plant Rafflesia lagascae (Rafflesiaceae)
Jeanmaire Molina,Khaled M. Hazzouri,Daniel L. Nickrent,Matt Geisler,Rachel S. Meyer,Melissa M. Pentony,Jonathan M. Flowers,Jonathan M. Flowers,Pieter B. Pelser,Julie F. Barcelona,Samuel Alan Inovejas,Iris Diana Uy,Wei Yuan,Olivia Wilkins,Claire Iphanise Michel,Selina Locklear,Gisela P. Concepcion,Michael D. Purugganan,Michael D. Purugganan +18 more
TL;DR: The inability to identify substantial plastid genome sequences from R. lagascae using multiple approaches suggests that the parasitic plant genus Rafflesia may be the first plant group for which there is no recognizable plastids genome, or if present is found in cryptic form at very low levels.
Journal ArticleDOI
Isolation, structure determination, and biological activity of a novel alkaloid, perophoramidine, from the Philippine ascidian Perophora namei.
TL;DR: Dehalogenation of perophoramidine by ammonium formate catalyzed transfer hydrogenation confirmed the type and number of halogen atoms present in 1.
Journal ArticleDOI
Aldisine Alkaloids from the Philippine Sponge Stylissa massa Are Potent Inhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1)
Deniz Tasdemir,Robert Mallon,Michael Greenstein,Larry Feldberg,Steven C. Kim,Karen Collins,Donald Wojciechowicz,Gina C. Mangalindan,Gisela P. Concepcion,Mary Kay Harper,Chris M. Ireland +10 more
TL;DR: Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids and compounds 4 and 5 showed significant enzyme inhibitory activity, identified as potent MEK- 1 inhibitors.