M
Maria Divina E. Deato
Researcher at University of California, Berkeley
Publications - 2
Citations - 291
Maria Divina E. Deato is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Transcription Factor TFIID & Myogenesis. The author has an hindex of 2, co-authored 2 publications receiving 281 citations.
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Switching of the core transcription machinery during myogenesis
TL;DR: It is reported that differentiation of myoblast to myotubes involves the disruption of the canonical holo-TFIID and replacement by a novel TRF3/TAF3 (TBP-related factor 3/TATA-binding protein-associated factor 3) complex, which provides organisms a simple yet effective means to selectively turn on one transcriptional program while silencing many others.
Journal ArticleDOI
MyoD targets TAF3/TRF3 to activate myogenin transcription.
TL;DR: This development of a purified reconstituted system to analyze the properties of a TAF3/TRF3 complex in directing transcription initiation at the Myogenin promoter allows a more balanced division of labor between activators and TAF coactivators, thus providing another strategy to accommodate cell-specific regulation during metazoan development.