Maria F. Troncoso

TL;DR: NIV and CPAP were more effective than lifestyle modification in improving clinical symptoms and polysomnographic parameters, although NIV yielded better respiratory functional improvements than did CPAP.

TL;DR: In stable patients with obesity hypoventilation syndrome and severe obstructive sleep apnoea, non-invasive ventilation and continuous positive airway pressure have similar long-term effectiveness.

TL;DR: Sleepiness, some health-related quality of life assessments and polysomnographic parameters improved significantly more with NIV than with lifestyle modification, and there was a tendency towards lower healthcare resource utilisation in the NIV group.

TL;DR: In patients with OHS, the highest OSA severity phenotype was associated with reduced risk of CVM, and this finding should guide the design of future clinical trials assessing the impact of interventions aimed at decreasing cardiovascular morbidity and mortality in patients withOHS.

TL;DR: A large multicenter randomized controlled study to determine the comparative efficacy of NIV, CPAP, and lifestyle modification in patients with severe sleep apnea, finding NIV yielded the greatest improvement in PaCO2 and bicarbonate, with significant differences relative to the control.