Jesús Sanchez-Gómez

TL;DR: In stable patients with obesity hypoventilation syndrome and severe obstructive sleep apnoea, non-invasive ventilation and continuous positive airway pressure have similar long-term effectiveness.

TL;DR: Sleepiness, some health-related quality of life assessments and polysomnographic parameters improved significantly more with NIV than with lifestyle modification, and there was a tendency towards lower healthcare resource utilisation in the NIV group.

TL;DR: In patients with OHS, the highest OSA severity phenotype was associated with reduced risk of CVM, and this finding should guide the design of future clinical trials assessing the impact of interventions aimed at decreasing cardiovascular morbidity and mortality in patients withOHS.

TL;DR: Hospital discharge with PAP reduces mortality following acute-on-chronic hypercapnic respiratory failure in patients with OHS or suspected of having OHS, and well-designed clinical trials are needed to confirm this finding.

TL;DR: The Pickwick project was a prospective, randomized and controlled study, which addressed the issue of obesity hypoventilation syndrome, a growing problem in developed countries, and evaluated the efficacy of NIV treatment, CPAP and lifestyle changes in the medium and long-term management of patients with OHS.