M
Maria G. Frid
Researcher at Anschutz Medical Campus
Publications - 98
Citations - 8970
Maria G. Frid is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Hypoxia (medical) & Pulmonary hypertension. The author has an hindex of 47, co-authored 93 publications receiving 8087 citations. Previous affiliations of Maria G. Frid include USSR Academy of Medical Sciences & University of Colorado Denver.
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Journal ArticleDOI
Hypoxia-Induced Pulmonary Vascular Remodeling Cellular and Molecular Mechanisms
TL;DR: The hypoxia-induced remodeling of the pulmonary circulation is a highly complex process where numerous interactive events must be taken into account as the authors search for newer, more effective therapeutic interventions.
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Mature vascular endothelium can give rise to smooth muscle cells via endothelial-mesenchymal transdifferentiation: in vitro analysis.
TL;DR: In vitro data show that mature bovine systemic and pulmonary endothelium contains cells that can acquire a SM phenotype via a transdifferentiation process that is transforming growth factor-&bgr;1– and cell-cell contact–dependent, but proliferation-independent.
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Hypoxia-Induced Pulmonary Vascular Remodeling Requires Recruitment of Circulating Mesenchymal Precursors of a Monocyte/Macrophage Lineage
Maria G. Frid,Jacqueline A. Brunetti,Danielle L. Burke,Todd C. Carpenter,Neil Davie,John T. Reeves,Mark T. Roedersheimer,Nico van Rooijen,Kurt R. Stenmark +8 more
TL;DR: It is concluded that circulating mesenchymal precursors of a monocyte/macrophage lineage, including fibrocytes, are essential contributors to hypoxia-induced pulmonary vascular remodeling.
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Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
Aimee Y. Yu,Maria G. Frid,Larissa A. Shimoda,Charles M. Wiener,Kurt R. Stenmark,Gregg L. Semenza +5 more
TL;DR: Findings demonstrate that Hif-1 expression is tightly coupled to O2 concentration in vivo and are consistent with the involvement of HIF-1 in the physiological and pathophysiological responses to hypoxia in the lung.
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The Adventitia: Essential Regulator of Vascular Wall Structure and Function
Kurt R. Stenmark,Michael E. Yeager,Karim C. El Kasmi,Eva Nozik-Grayck,Evgenia V. Gerasimovskaya,Min Li,Suzette R. Riddle,Maria G. Frid +7 more
TL;DR: This review presents the current evidence demonstrating that the adventitia acts as a key regulator of vascular wall function and structure from the outside in.