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Aimee Y. Yu
Researcher at Johns Hopkins University School of Medicine
Publications - 7
Citations - 4648
Aimee Y. Yu is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Vascular endothelial growth factor & Hypoxia (medical). The author has an hindex of 7, co-authored 7 publications receiving 4435 citations. Previous affiliations of Aimee Y. Yu include Johns Hopkins University.
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Journal ArticleDOI
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
Narayan V. Iyer,Lori E. Kotch,Faton Agani,Sandra W. Leung,Erik Laughner,Roland H. Wenger,Max Gassmann,John D. Gearhart,Ann M. Lawler,Aimee Y. Yu,Gregg L. Semenza +10 more
TL;DR: It is demonstrated that HIF-1alpha is a master regulator of cellular and developmental O2 homeostasis in Hif1a-/- embryos that manifested neural tube defects, cardiovascular malformations, and marked cell death within the cephalic mesenchyme.
Journal ArticleDOI
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
Aimee Y. Yu,Larissa A. Shimoda,Narayan V. Iyer,David L. Huso,Xing Sun,Rita McWilliams,Terri H. Beaty,James S.K. Sham,Charles M. Wiener,J. T. Sylvester,Gregg L. Semenza +10 more
TL;DR: It is shown that partial HIF-1alpha deficiency has significant effects on multiple systemic responses to chronic hypoxia, and significantly greater weight loss compared with wild-type littermates.
Journal ArticleDOI
Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain
Marcelle Bergeron,Jeffrey M. Gidday,Aimee Y. Yu,Gregg L. Semenza,Donna M. Ferriero,Frank R. Sharp,Frank R. Sharp +6 more
TL;DR: HIF‐1 activation could contribute to protective brain preconditioning, which could be used in high‐risk deliveries and other clinical situations.
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Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain.
TL;DR: This is the first study to show induction of HIF‐1 after focal ischaemia in brain, and it is proposed that decreased blood flow to the penumbra decreases the supply of oxygen and that this induces Hif‐1 and its target genes.
Journal ArticleDOI
Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung
Aimee Y. Yu,Maria G. Frid,Larissa A. Shimoda,Charles M. Wiener,Kurt R. Stenmark,Gregg L. Semenza +5 more
TL;DR: Findings demonstrate that Hif-1 expression is tightly coupled to O2 concentration in vivo and are consistent with the involvement of HIF-1 in the physiological and pathophysiological responses to hypoxia in the lung.