Maria Grazia Bisconte

TL;DR: Hepatocellular carcinoma (HCC) frequently complicates hepatic cirrhosis secondary to viral infection or iron overload, and patients affected by thalassaemia syndromes have a theoretically high risk of developing the tumour.

TL;DR: The cohort of patients treated with oral deferiprone showed less myocardial iron burden and better global systolic ventricular function compared to the patients treatedwith oral deferasirox or subcutaneous desferrioxamine.

TL;DR: The management of β-TM patients undergoing transfusions and ICT is efficacious, although costly, but overall benefits were not always perceived as optimal by patients, so efforts must be focused to improve patients' acceptance and satisfaction with their therapy.

TL;DR: Pancreatic iron is a powerful predictor not only for glucose metabolism but also for cardiac iron and complications, supporting the close link between pancreatic iron and heart disease and the need to intensify iron chelation therapy to prevent both alterations of glucose metabolism and cardiac iron accumulation.

TL;DR: Biallelic mutations in SEC23B gene cause congenital dyserythropoietic anemia type II (CDAII), an autosomal recessive disorder characterized by ineffective erythropOiesis, hemolytic anemia, and splenomegaly.