María Isabel Colombo

TL;DR: How bacteria manipulate small Rab GTPases to control many of these processes, including replicative vacuole formation, apoptosis, cytokine responses, and autophagy, are focused on.

TL;DR: The results indicate that VP3 localizes to vesicular structures bearing features of early and late endocytic compartments located in the juxtanuclear region, which constitutes the first study elucidating the localization of IBDV replication complexes and establishing a role for the Golgi apparatus in the assembly step of a birnavirus.

TL;DR: Some strategies employed by bacterial pathogens to modulate autophagy to their own benefit and, on the other hand, the role of Autophagy as a protective process of the host cell is summarized.

TL;DR: The results indicate that the GTPase Rab5 is crucial for I BDV entry supporting the participation of the early endosomal pathway in IBDV internalization and infection of susceptible cells.

TL;DR: The data showed that depleting intracellular polyamines by inhibiting the biosynthetic enzyme ornithine decarboxylase with difluoromethylornithine (DFMO) suppressed the induction of autophagy in response to starvation or rapamycin treatment in two cell lines, suggesting DFMO is an FDA-approved drug that may have value in limiting Autophagy and the spread of the infection in Chagas disease and possibly other pathological settings.