M
María-Luisa Jimeno
Researcher at Spanish National Research Council
Publications - 54
Citations - 507
María-Luisa Jimeno is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Moiety & Nucleic acid. The author has an hindex of 13, co-authored 54 publications receiving 475 citations. Previous affiliations of María-Luisa Jimeno include University of Palermo & Rega Institute for Medical Research.
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Journal ArticleDOI
Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.
Mohamed Benchekroun,Manuela Bartolini,Javier Egea,Alejandro Romero,Elena Soriano,Marc Pudlo,Vincent Luzet,Vincenza Andrisano,María-Luisa Jimeno,Manuela G. López,Sarah Wehle,Tijani Gharbi,Bernard Refouvelet,Lucía de Andrés,Clara Herrera-Arozamena,Barbara Monti,Maria Laura Bolognesi,María Isabel Rodríguez-Franco,Michael Decker,José Marco-Contelles,Lhassane Ismaili +20 more
TL;DR: The design, multicomponent synthesis, and biological, molecular modeling and ADMET studies, as well as in vitro PAMPA‐blood–brain barrier (BBB) analysis, support the development of new multipotent TFAH derivatives as potential drugs for the treatment of Alzheimer′s disease.
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Synthesis and pharmacological assessment of diversely substituted pyrazolo(3,4-b)quinoline, and benzo(b)pyrazolo(4,3-g)(1,8)naphthyridine derivatives
Daniel Silva,Daniel Silva,Mourad Chioua,Abdelouahid Samadi,M. Carmo Carreiras,María-Luisa Jimeno,Eduarda Mendes,Cristóbal de los Ríos,Alejandro Romero,Alejandro Romero,Mercedes Villarroya,Manuela G. López,José Marco-Contelles +12 more
TL;DR: The biological evaluation and pharmacological analyses showed that pyrazolotacrines 1-6 are inhibitors of Electrophorus electricus acetylcholinesterase (EeAChE), in the micromolar range, and quite selective in respect to serum horse butyrylcholinease (eqBuChE) inhibition.
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9-Arylpurines as a novel class of enterovirus inhibitors
Leire Aguado,Hendrik Jan Thibaut,Eva María Priego,María-Luisa Jimeno,María-José Camarasa,Johan Neyts,María-Jesús Pérez-Pérez +6 more
TL;DR: The most selective compounds in this series inhibited Coxsackie virus B3 replication in a dose-dependent manner with EC(50) values around 5-8 microM and no toxicity on different cell lines was observed at concentrations up to 250 microM.
Journal ArticleDOI
A neo-clerodane diterpenoid from Scutellaria baicalensis
Ahmed Hussein,María C. de la Torre,María-Luisa Jimeno,Benjamín Rodríguez,Maurizio Bruno,Franco Piozzi,Orietta Servettaz +6 more
TL;DR: An acetone extract of the aerial parts of Scutellaria baicalensis provided a new neo-clerodane, scutebaicalin, the structure of which was established as 6α,7β-dibenzoyloxy-8β-hydroxy-neo-cleroda-4(18),13-dien-15,16-olide by spectroscopic means as mentioned in this paper.
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Potential multifunctional inhibitors of HIV-1 reverse transcriptase. Novel [AZT]-[TSAO-T] and [d4T]-[TSAO-T] heterodimers modified in the linker and in the dideoxynucleoside region
Sonsoles Velázquez,V. Tunon,María-Luisa Jimeno,Cristina Chamorro,E. De Clercq,Jan Balzarini,María-José Camarasa +6 more
TL;DR: Among the novel heterodimers, several derivatives show a potent anti-HIV-1 activity, which proved comparable, or even superior, to that of the AZT heterodimer prototype.