M
Maria Mirotsou
Researcher at Duke University
Publications - 40
Citations - 3435
Maria Mirotsou is an academic researcher from Duke University. The author has contributed to research in topics: Mesenchymal stem cell & Paracrine signalling. The author has an hindex of 19, co-authored 39 publications receiving 3009 citations. Previous affiliations of Maria Mirotsou include Brigham and Women's Hospital & Durham University.
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Journal ArticleDOI
MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes
Tilanthi M. Jayawardena,Bakytbek Egemnazarov,Elizabeth A. Finch,Lunan Zhang,J. Alan Payne,Kumar Pandya,Zhiping Zhang,Paul B. Rosenberg,Maria Mirotsou,Victor J. Dzau +9 more
TL;DR: The findings from this study provide proof-of-concept that miRNAs have the capability of directly converting fibroblasts to a cardiomyocyte-like phenotype in vitro, and are the first report of direct cardiac reprogramming in vivo.
Journal ArticleDOI
Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair
Maria Mirotsou,Zhongyan Zhang,Arjun Deb,Lunan Zhang,Massimiliano Gnecchi,Nicolas Noiseux,Hui Mu,Alok S. Pachori,Victor J. Dzau +8 more
TL;DR: The key role played by Sfrp2 in mediating the paracrine effects of Akt-mesenchymal stem cells on tissue repair is revealed and modulation of Wnt signaling is identified as a therapeutic target for heart disease.
Journal ArticleDOI
Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.
Maria Mirotsou,Tilanthi M. Jayawardena,Jeffrey Schmeckpeper,Massimiliano Gnecchi,Victor J. Dzau +4 more
TL;DR: The potential for diverse stem cell populations to moderate many of the same processes as well as key paracrine factors and molecular pathways involved in stem cell-mediated cardiac repair will be discussed in this review.
OtherDOI
Classical Renin‐Angiotensin System in Kidney Physiology
Matthew A. Sparks,Steven D. Crowley,Steven D. Crowley,Susan B. Gurley,Susan B. Gurley,Maria Mirotsou,Thomas M. Coffman,Thomas M. Coffman,Thomas M. Coffman +8 more
TL;DR: The physiological role of components of the "classical" renin-angiotensin system is reviewed, with an emphasis on new developments and modern concepts.
Journal ArticleDOI
Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium
Jing Huang,Zhiping Zhang,Jian Guo,Aiguo Ni,Arjun Deb,Lunan Zhang,Maria Mirotsou,Richard E. Pratt,Victor J. Dzau +8 more
TL;DR: In vitro and in vivo overexpression of chemokine receptor enhances the migration, survival and engraftment of MSCs, and may provide a new therapeutic strategy for the injured myocardium.