P
Paul B. Rosenberg
Researcher at Johns Hopkins University School of Medicine
Publications - 221
Citations - 14207
Paul B. Rosenberg is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Dementia & Randomized controlled trial. The author has an hindex of 54, co-authored 220 publications receiving 11975 citations. Previous affiliations of Paul B. Rosenberg include Johns Hopkins Bayview Medical Center & United States Department of Veterans Affairs.
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Journal ArticleDOI
A Mutation in the TRPC6 Cation Channel Causes Familial Focal Segmental Glomerulosclerosis
Michelle P. Winn,Peter J. Conlon,Kelvin L. Lynn,Merry Kay Farrington,Tony Creazzo,April F. Hawkins,Nikki Daskalakis,Shu Ying Kwan,Seth M. Ebersviller,James L. Burchette,Margaret A. Pericak-Vance,David N. Howell,Jeffery M. Vance,Paul B. Rosenberg +13 more
TL;DR: In this article, a large family with hereditary FSGS carries a missense mutation in the TRPC6 gene on chromosome 11q, encoding the ion-channel protein transient receptor potential cation channel 6 (TRPC6).
Journal ArticleDOI
MicroRNA-Mediated In Vitro and In Vivo Direct Reprogramming of Cardiac Fibroblasts to Cardiomyocytes
Tilanthi M. Jayawardena,Bakytbek Egemnazarov,Elizabeth A. Finch,Lunan Zhang,J. Alan Payne,Kumar Pandya,Zhiping Zhang,Paul B. Rosenberg,Maria Mirotsou,Victor J. Dzau +9 more
TL;DR: The findings from this study provide proof-of-concept that miRNAs have the capability of directly converting fibroblasts to a cardiomyocyte-like phenotype in vitro, and are the first report of direct cardiac reprogramming in vivo.
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Exercise Stimulates Pgc-1α Transcription in Skeletal Muscle through Activation of the p38 MAPK Pathway
Takayuki Akimoto,Steven C. Pohnert,Ping Li,Mei Zhang,Curtis Gumbs,Paul B. Rosenberg,R. Sanders Williams,Zhen Yan +7 more
TL;DR: It is reported that a single bout of voluntary running induced a transient increase of Pgc-1α mRNA expression in mouse plantaris muscle, concurrent with an activation of the p38 MAPK pathway, suggesting that contractile activity-induced activation ofThe p38MAPK pathway promotes PGC-1 α gene expression and skeletal muscle adaptation.
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In vivo imaging of amyloid deposition in Alzheimer disease using the radioligand 18F-AV-45 (florbetapir [corrected] F 18).
Dean F. Wong,Paul B. Rosenberg,Yun Zhou,Anil Kumar,Vanessa Raymont,Hayden T. Ravert,Robert F. Dannals,Ayon Nandi,James Robert Brašić,Weiguo Ye,John Hilton,Constantine G. Lyketsos,Hank F. Kung,Abhinay Joshi,Daniel Skovronsky,Daniel Skovronsky,Michael Pontecorvo +16 more
TL;DR: 18F-AV-45 was well tolerated, and PET showed significant discrimination between AD patients and HCs, using either a parametric reference region method (DVR) or a simplified SUVR calculated from 10 min of scanning 50–60 min after 18F- AV-45 administration.
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Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial
Anton P. Porsteinsson,Lea T. Drye,Bruce G. Pollock,Devangere P. Devanand,Constantine Frangakis,Zahinoor Ismail,Christopher Marano,Curtis L. Meinert,Jacobo Mintzer,Cynthia A. Munro,Gregory H. Pelton,Peter V. Rabins,Paul B. Rosenberg,Lon S. Schneider,David M. Shade,Daniel Weintraub,Jerome A. Yesavage,Jerome A. Yesavage,Constantine G. Lyketsos +18 more
TL;DR: Among patients with probable Alzheimer disease and agitation who were receiving psychosocial intervention, the addition of citalopram compared with placebo significantly reduced agitation and caregiver distress; however, cognitive and cardiac adverse effects of cITALopram may limit its practical application at the dosage of 30 mg per day.