M
Maria Norlin
Researcher at Uppsala University
Publications - 45
Citations - 1196
Maria Norlin is an academic researcher from Uppsala University. The author has contributed to research in topics: Vitamin D and neurology & CYP7B1. The author has an hindex of 17, co-authored 42 publications receiving 1082 citations.
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Journal ArticleDOI
Enzymes in the Conversion of Cholesterol into Bile Acids
Maria Norlin,Kjell Wikvall +1 more
TL;DR: The enzymes, nuclear receptors and transcription factors involved in bile acid biosynthesis are potential pharmaceutical targets for the development of new drugs to control hypercholesterolemia and to prevent atherosclerosis and other diseases related to disturbed cholesterol homeostasis.
Journal ArticleDOI
Metabolism of 4β-Hydroxycholesterol in Humans
Karl Bodin,Ulla Andersson,Eva Rystedt,Ewa Ellis,Maria Norlin,Irina A. Pikuleva,Gösta Eggertsen,Ingemar Björkhem,Ulf Diczfalusy +8 more
TL;DR: The results suggest that the high plasma concentration of 4β-hydroxycholesterol is because of its exceptionally slow elimination, probably in part because of the low rate of 7α-hydroxylation of the steroid.
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Regulation of Human Vitamin D3 25-Hydroxylases in Dermal Fibroblasts and Prostate Cancer LNCaP Cells
TL;DR: New information is provided indicating that 25-hydroxylation of vitamin D3 may be regulated and may offer a possible explanation for the impaired bone health after treatment with certain drugs.
Journal ArticleDOI
24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)
TL;DR: The results show that 24-hydroxycholesterol is metabolized by CYP7A, an enzyme previously considered to be specific for cholesterol and cholestanol and not active toward oxysterols, which is the rate-limiting enzyme in the major pathway of bile acid biosynthesis.
Journal ArticleDOI
1α,25-Dihydroxyvitamin D3 affects hormone production and expression of steroidogenic enzymes in human adrenocortical NCI-H295R cells
TL;DR: Novel findings are reported on 1alpha,25-dihydroxyvitamin D(3)-mediated effects on hormone production and regulation of genes and enzymes involved in steroidogenesis in the adrenocortical NCI-H295R cell line, a model for human adrenal cortex.