U
Ulla Andersson
Researcher at Karolinska Institutet
Publications - 25
Citations - 1776
Ulla Andersson is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Cholesterol 7 alpha-hydroxylase & CYP8B1. The author has an hindex of 20, co-authored 25 publications receiving 1648 citations. Previous affiliations of Ulla Andersson include University of Texas Southwestern Medical Center & University of Texas Medical Branch.
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Journal ArticleDOI
Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
Jia Li-Hawkins,Mats Gåfvels,Maria Olin,Erik G. Lund,Ulla Andersson,Gertrud U. Schuster,Ingemar Björkhem,David W. Russell,Gösta Eggertsen +8 more
TL;DR: The results implicate cholate as an important negative regulator of bile acid synthesis and provide preliminary evidence for ligand-specific gene activation by a nuclear receptor.
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Metabolism of 4β-Hydroxycholesterol in Humans
Karl Bodin,Ulla Andersson,Eva Rystedt,Ewa Ellis,Maria Norlin,Irina A. Pikuleva,Gösta Eggertsen,Ingemar Björkhem,Ulf Diczfalusy +8 more
TL;DR: The results suggest that the high plasma concentration of 4β-hydroxycholesterol is because of its exceptionally slow elimination, probably in part because of the low rate of 7α-hydroxylation of the steroid.
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Brain cholesterol synthesis in mice is affected by high dose of simvastatin but not of pravastatin.
Karin M. Thelen,Katharina Rentsch,Ursula Gutteck,Maura Heverin,Maria Olin,Ulla Andersson,Arnold von Eckardstein,Ingemar Björkhem,Dieter Lütjohann +8 more
TL;DR: It is concluded that brain cholesterol synthesis is significantly affected by short-term treatment with high doses of lipophilic simvastatin, whereas whole-brain cholesterol turnover is not disturbed.
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Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.
Yoshihiko Ohyama,Yoshihiko Ohyama,Steve Meaney,Maura Heverin,Lena Ekström,Anat Brafman,Millicent Shafir,Ulla Andersson,Maria Olin,Gösta Eggertsen,Ulf Diczfalusy,Elena Feinstein,Ingemar Björkhem +12 more
TL;DR: A structural and functional characterization of the promoter of the human CYP46A1 gene is made and the failure to demonstrate a significant transcriptional regulation under most conditions is discussed in relation to the turnover of brain and neuronal cholesterol.
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Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid
Steve Meaney,Maura Heverin,Ute Panzenboeck,Lena Ekström,Magnus Axelsson,Ulla Andersson,Ulf Diczfalusy,Irina A. Pikuleva,John Wahren,Wolfgang Sattler,Ingemar Björkhem +10 more
TL;DR: The studies identify a novel metabolic route for the elimination of 27-hydroxylated sterols from the brain and demonstrate that 7α-hydroxy-3-oxo-4-cholestenoic acid is efficiently transferred across monolayers of primary brain microvascular endothelial cells.