M
María Romina Girotti
Researcher at University of Buenos Aires
Publications - 7
Citations - 387
María Romina Girotti is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Stromal cell & Osteonectin. The author has an hindex of 6, co-authored 7 publications receiving 351 citations. Previous affiliations of María Romina Girotti include Facultad de Ciencias Exactas y Naturales & Fundación Instituto Leloir.
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Journal ArticleDOI
The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host.
Osvaldo L. Podhajcer,Lorena Benedetti,María Romina Girotti,Federico Prada,Edgardo Salvatierra,Andrea S. Llera +5 more
TL;DR: The most recent evidence that links SPARC with human cancer progression, the controversy regarding its role in certain human cancers and the physiological processes in which SPARC is involved: epithelial–mesenchymal transition, immune surveillance and angiogenesis are described.
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SPARC Promotes Cathepsin B-Mediated Melanoma Invasiveness through a Collagen I/α2β1 Integrin Axis
María Romina Girotti,Marisol Fernández,Juan Antonio López,Emilio Camafeita,Elmer Andrés Fernández,Juan Pablo Albar,Lorena Benedetti,María P. Valacco,Rolf A. Brekken,Osvaldo L. Podhajcer,Andrea S. Llera +10 more
TL;DR: A previously unreported molecular pathway for SPARC activity on invasion is demonstrated and an active role of SPARC in the mesenchymal transformation that contributes to melanoma dissemination is supported.
Journal ArticleDOI
Proteomic analysis identified N-cadherin, clusterin, and HSP27 as mediators of SPARC (secreted protein, acidic and rich in cysteines) activity in melanoma cells.
Maria Soledad Sosa,Maria Soledad Sosa,María Romina Girotti,Edgardo Salvatierra,Federico Prada,Juan Antonio López de Olmo,Juan Antonio López de Olmo,Silvia Juárez Gallango,Juan Pablo Albar,Osvaldo Podhajcer,Andrea S. Llera +10 more
TL;DR: Results constitute the first evidence that SPARC, N‐CAD, CLU, and HSP27 converge in a unique molecular network in melanoma cells.
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ATP‐dependent modulation and autophosphorylation of rapeseed 2‐Cys peroxiredoxin
Martin Aran,Daniel Caporaletti,Alejandro M. Senn,María T. Tellez de Iñon,María Romina Girotti,Andrea S. Llera,Ricardo A. Wolosiuk +6 more
TL;DR: The functional coupling between ATP and 2‐Cys Prx gives novel insights into not only the removal of reactive oxygen species, but also mechanisms that link the energy status of the cell and the oxidation of cysteine residues.
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Matricellular proteins and inflammatory cells: a task force to promote or defeat cancer?
TL;DR: The evidence available up to date that relates matricellular proteins with the regulation of the inflammatory response and tumor progression is discussed.