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Maria Rosaria Del Giudice

Researcher at Istituto Superiore di Sanità

Publications -  37
Citations -  540

Maria Rosaria Del Giudice is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Nociceptin receptor & NOP. The author has an hindex of 14, co-authored 37 publications receiving 512 citations.

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Journal ArticleDOI

Synthesis of pyrazolo[1,5‐a]‐, 1,2,4‐triazolo[1,5‐a]‐ and imidazo[1,2‐a]pyrimidines related to zaleplon, a new drug for the treatment of insomnia

Carlo Mustazza, +3 more
- 01 Sep 2001 - 
TL;DR: In this paper, the preparation of pyrazolo[1,5-a]-, 1,2,4-triazolo[ 1,5a]- and imidazo[1.2]-pyrimidines substituted on the pyrimidine moiety by a 4-[(N-acetyl-N-ethyl)amino]phenyl group was described.
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Development of a tandem thin-layer chromatography–high-performance liquid chromatography method for the identification and determination of corticosteroids in cosmetic products

Luigi Gagliardi, +6 more
- 22 Apr 2002 - 
TL;DR: In this paper, a thin-layer chromatographic analysis was carried out on silica gel plates, using different eluants and detection reagents, and the analytical recoveries were satisfactory.
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Synthesis and Evaluation as NOP Ligands of Some Spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones and Spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines]

Carlo Mustazza, +6 more
- 01 May 2006 - 
TL;DR: Some spiro[piperidine-4,2'(1'H)-quinazolin]-4'(3' H)-ones 3 and spiro:[1,2,4]triazolo[1,5-c]quinazolines 4 were synthesized and evaluated as ligands of the nociceptin receptor.
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A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists.

Isabella Sestili, +7 more
- 01 Dec 2004 - 
TL;DR: A series of 4-amino-2-methylquinoline and 4-AMinoquinazoline derivatives, including the reference NOP antagonist JTC-801, were synthesized by an alternative pathway and their in vitro pharmacological properties were investigated.
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Synthesis and cholinesterase activity of phenylcarbamates related to Rivastigmine, a therapeutic agent for Alzheimer's disease.

Carlo Mustazza, +7 more
- 01 Feb 2002 - 
TL;DR: 1-[1-(3-dimethylcarbamoyloxyphenyl)ethyl]piperidine (31b), in addition to a simple and cheaper synthesis, showed lower toxicity and very similar therapeutic index in comparison with Rivastigmine.