M
Marialuisa Lavitrano
Researcher at University of Milano-Bicocca
Publications - 146
Citations - 4527
Marialuisa Lavitrano is an academic researcher from University of Milano-Bicocca. The author has contributed to research in topics: Sperm-mediated gene transfer & Cancer. The author has an hindex of 33, co-authored 131 publications receiving 4065 citations. Previous affiliations of Marialuisa Lavitrano include Sapienza University of Rome & University of Milan.
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Journal ArticleDOI
Sperm cells as vectors for introducing foreign DNA into eggs: genetic transformation of mice.
Marialuisa Lavitrano,Antonella Camaioni,Vito Michele Fazio,Susanna Dolci,Maria Giulia Farace,Maria Giulia Farace,Corrado Spadafora +6 more
TL;DR: It is concluded that transgenic mice can be obtained using sperm cells as foreign DNA vectors and CAT gene expression was detected on tissues of adult F1 individuals, preferentially on tails and muscle.
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Efficient production by sperm-mediated gene transfer of human decay accelerating factor (hDAF) transgenic pigs for xenotransplantation
Marialuisa Lavitrano,Maria Laura Bacci,Monica Forni,Davide Lazzereschi,Carla Di Stefano,Daniela Fioretti,Paola Giancotti,Gabriella Marfe,Loredana Pucci,Luigina Renzi,Hongjun Wang,Antonella Stoppacciaro,Giorgio Stassi,Massimo Sargiacomo,Paola Sinibaldi,Valeria Turchi,Roberto Giovannoni,Giacinto Della Casa,Eraldo Seren,Giancarlo Rossi +19 more
TL;DR: Results show that the SMGT approach to transgenesis provides an efficient procedure for studies involving large animal models and was functional based on in vitro experiments performed on peripheral blood mononuclear cells.
Journal ArticleDOI
Sperm-mediated gene transfer
Marialuisa Lavitrano,Marco Busnelli,Maria Grazia Cerrito,Roberto Giovannoni,Stefano Manzini,Alessia Vargiolu +5 more
TL;DR: Sperm-mediated gene transfer could be used to generate multigene transgenic pigs that would be of benefit as large animal models for medical research, for agricultural and pharmaceutical applications and, in particular, for xenotransplantation, which requires extensive genetic manipulation of donor pigs to make them suitable for grafting to humans.
Journal ArticleDOI
The interaction between exogenous DNA and sperm cells.
TL;DR: The presence of a specific binding protein for the DNA and of a factor inhibiting such interaction support the existence of a mechanism controlling, through specific factors, the sperm–DNA interaction.
Journal ArticleDOI
The mechanism of binding of exogenous dna to sperm cells : factors controlling the dna uptake
Massimo Zani,Marialuisa Lavitrano,Deborah French,Valentina Lulli,B. Maione,Sabina Sperandio,Corrado Spadafora +6 more
TL;DR: The interaction of exogenous DNA with sperm cells does not appear to be a casual event but, on the contrary, relies on a molecular mechanism based on the cooperation of specific protein factors.