G
Giorgio Stassi
Researcher at University of Palermo
Publications - 203
Citations - 21653
Giorgio Stassi is an academic researcher from University of Palermo. The author has contributed to research in topics: Cancer stem cell & Stem cell. The author has an hindex of 65, co-authored 188 publications receiving 19433 citations. Previous affiliations of Giorgio Stassi include Istituto Superiore di Sanità & Thomas Jefferson University.
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Journal ArticleDOI
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Louis Vermeulen,Felipe De Sousa E Melo,Maartje van der Heijden,Kate Cameron,Joan H. de Jong,Tijana Borovski,Jurriaan B. Tuynman,Matilde Todaro,Christian Merz,Hans M. Rodermond,Martin R. Sprick,Kristel Kemper,Dick J. Richel,Giorgio Stassi,Jan Paul Medema +14 more
TL;DR: It is proposed that stemness of colon cancer cells is in part orchestrated by the microenvironment and is a much more dynamic quality than previously expected that can be defined by high Wnt activity.
Journal ArticleDOI
Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
Lucia Ricci-Vitiani,Roberto Pallini,Mauro Biffoni,Matilde Todaro,Gloria Invernici,Tonia Cenci,Giulio Maira,Eugenio Parati,Giorgio Stassi,Luigi Maria Larocca,Ruggero De Maria +10 more
TL;DR: A variable number (range 20–90%, mean 60.7%) of endothelial cells in glioblastoma carry the same genomic alteration as tumour cells, indicating that a significant portion of the vascular endothelium has a neoplastic origin.
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Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature.
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Julien Wicinski,Nathalie Cervera,Pascal Finetti,Min-Hee Hur,Mark E. Diebel,Florence Monville,Julie Dutcher,Marthy Brown,Patrice Viens,Luc Xerri,François Bertucci,Giorgio Stassi,Gabriela Dontu,Daniel Birnbaum,Max S. Wicha +17 more
TL;DR: It is shown that ALDEFLUOR-positive cells are responsible for mediating metastasis and the hierarchical organization of immortalized cell lines, establish techniques that can facilitate the characterization of regulatory pathways of CSCs, and identify potential stem cell markers and therapeutic targets.
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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.
Matilde Todaro,Mileidys Perez Alea,Anna Barbara Di Stefano,Patrizia Cammareri,Louis Vermeulen,Flora Iovino,Claudio Tripodo,Antonio Russo,Gaspare Gulotta,Jan Paul Medema,Giorgio Stassi +10 more
TL;DR: The data suggest that colon tumor growth is dictated by stem-like cells that are treatment resistant due to the autocrine production of IL-4, which strongly enhances the antitumor efficacy of standard chemotherapeutic drugs through selective sensitization of CD133(+) cells.
Journal ArticleDOI
Aldehyde Dehydrogenase 1–Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer
Emmanuelle Charafe-Jauffret,Christophe Ginestier,Flora Iovino,Carole Tarpin,Mark E. Diebel,Benjamin Esterni,Gilles Houvenaeghel,Jean-Marc Extra,François Bertucci,François Bertucci,Jocelyne Jacquemier,Luc Xerri,Luc Xerri,Gabriela Dontu,Giorgio Stassi,Yi Xiao,Sanford H. Barsky,Daniel Birnbaum,Patrice Viens,Max S. Wicha +19 more
TL;DR: AlDH1 expression represents the first independent prognostic marker to predict metastasis and poor patient outcome in IBC and suggests that the metastatic, aggressive behavior of IBC may be mediated by a CSC component that displays ALDH enzymatic activity.